Title:
MULTIMODAL TRAIL MOLECULES AND USES IN CELLULAR THERAPIES
Document Type and Number:
WIPO Patent Application WO/2012/106281
Kind Code:
A3
Abstract:
Described herein are novel compositions comprising multimodal TRAIL agents and cells engineered to express such multimodal TRAIL agents, including cells encapsulated in a scaffold or matrix, for use in the treatment of disorders such as cancer.
Inventors:
SHAH KHALID (US)
Application Number:
PCT/US2012/023221
Publication Date:
December 06, 2012
Filing Date:
January 31, 2012
Export Citation:
Assignee:
GEN HOSPITAL CORP (US)
SHAH KHALID (US)
SHAH KHALID (US)
International Classes:
A61K38/17; A61K9/48; A61K35/12; A61K35/28; A61K35/30; A61K38/16; A61K47/30; C12N15/861
Foreign References:
| US6284236B1 | 2001-09-04 | |||
| US20090325867A1 | 2009-12-31 |
Other References:
KIRSHNER ET AL.: "Identification of TRAIL as an Interferon Regulatory Factor 3 Transcriptional Target", JOURNAL OF VIROLOGY, vol. 79, no. 14, July 2005 (2005-07-01), pages 9320 - 9324, XP055092494
SHAH ET AL.: "In Vivo Imaging of S-TRAIL-Mediated Tumor Regression and Apotosis", MOLECULAR THERAPY, vol. 11, no. 6, June 2005 (2005-06-01), pages 926 - 931, XP005002712
SHAH ET AL.: "In Vivo Imaging of S-TRAIL-Mediated Tumor Regression and Apotosis", MOLECULAR THERAPY, vol. 11, no. 6, June 2005 (2005-06-01), pages 926 - 931, XP005002712
Attorney, Agent or Firm:
RESNICK, David S. et al. (Nixon Peabody LLPBoston, Massachusetts, US)
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