Title:
MULTIPLE ANTIGEN BINDING MOLECULAR FUSION, PHARMACEUTICAL COMPOSITION, METHOD FOR IDENTIFYING LINEAR EPITOPE, AND METHOD FOR PREPARING MULTIPLE ANTIGEN BINDING MOLECULAR FUSION
Document Type and Number:
WIPO Patent Application WO/2016/182064
Kind Code:
A1
Abstract:
Provided is a multiple antigen binding molecular fusion including: a multiple antigen binding molecule (α) having an immune cell antigen binding region and a cancer antigen binding region; a cancer tissue-specific protease cleavage linker (β); and a masking molecule (γ) having a polypeptide with the amino acid sequence, QDGNE, wherein the multiple antigen binding molecule (α) and the masking molecule (γ) are linked through the cancer tissue-specific protease cleavage linker (β).
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Inventors:
IGAWA TOMOYUKI (JP)
HIRONIWA NAOKA (JP)
KAWAUCHI HIROKI (JP)
HIRONIWA NAOKA (JP)
KAWAUCHI HIROKI (JP)
Application Number:
PCT/JP2016/064301
Publication Date:
November 17, 2016
Filing Date:
May 13, 2016
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N15/09; A61K39/395; A61K47/42; A61K47/48; A61P35/00; C07K7/00; C07K14/00; C07K16/28; C07K16/32; C07K19/00; C12P21/08
Domestic Patent References:
| WO2014144722A2 | 2014-09-18 | |||
| WO2012073985A1 | 2012-06-07 | |||
| WO2015046554A1 | 2015-04-02 | |||
| WO2016046778A2 | 2016-03-31 | |||
| WO2016014974A2 | 2016-01-28 |
Foreign References:
| JP2015509952A | 2015-04-02 | |||
| JP2015509951A | 2015-04-02 | |||
| JP2013528569A | 2013-07-11 | |||
| JP2014519322A | 2014-08-14 |
Other References:
KJER-NIELSEN L ET AL.: "Crystal structure of the human T cell receptor CD 3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3", PROC. NATL. ACAD. SCI. USA, vol. 101, no. 20, 2004, pages 7675 - 7680, XP055329073
FERNANDES RA ET AL.: "T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.", J. BIOL. CHEM., vol. 287, no. 16, 2012, pages 13324 - 13335, XP055329084
PONOMARENKO J ET AL.: "ElliPro: a new structure-based tool for the prediction of antibody epitopes.", BMC BIOINFORMATICS, vol. 9, no. 514, 2008, pages 1 - 8, XP021041865
GUTHRIDGE JM ET AL.: "Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/ CD 21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface.", J. IMMUNOL., vol. 167, no. 10, 15 November 2001 (2001-11-15), pages 5758 - 5766, XP002318006
See also references of EP 3296395A4
FERNANDES RA ET AL.: "T cell receptors are structures capable of initiating signaling in the absence of large conformational rearrangements.", J. BIOL. CHEM., vol. 287, no. 16, 2012, pages 13324 - 13335, XP055329084
PONOMARENKO J ET AL.: "ElliPro: a new structure-based tool for the prediction of antibody epitopes.", BMC BIOINFORMATICS, vol. 9, no. 514, 2008, pages 1 - 8, XP021041865
GUTHRIDGE JM ET AL.: "Epitope mapping using the X-ray crystallographic structure of complement receptor type 2 (CR2)/ CD 21: identification of a highly inhibitory monoclonal antibody that directly recognizes the CR2-C3d interface.", J. IMMUNOL., vol. 167, no. 10, 15 November 2001 (2001-11-15), pages 5758 - 5766, XP002318006
See also references of EP 3296395A4
Attorney, Agent or Firm:
HARUNA, Masao et al. (JP)
Masao Haruna (JP)
Masao Haruna (JP)
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