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Patent Searching and Data


Title:
MULTIPLE LIQUID FLOW ELECTROSPRAY INTERFACE
Document Type and Number:
WIPO Patent Application WO2000018256
Kind Code:
A8
Abstract:
An apparatus for electrospray ionization of a liquid sample matrix to prepare the sample for introduction into a mass spectrometer. The inventive electrospray interface is arranged between a source of a liquid sample matrix and an electrospray ionization needle. The interface includes a central chamber which contains elements for passively mixing the liquid sample flow with a modifying liquid added to the central chamber through a side channel. The side channel is isolated from the central chamber by a flow restrictor and the modifying liquid is provided to the side channel through a valve. A second valve, side channel, and flow restrictor are used to permit introduction of a calibration fluid into the central chamber through the first side channel. The inventive interface permits mixing of a modifying liquid with the liquid sample matrix to assist in nebulization of the liquid sample by reducing the surface tension of the sample containing fluid.

Inventors:
WELLS GREGORY J
TONG ROGER C
YEE PETER P
Application Number:
US9922447W
Publication Date:
August 24, 2000
Filing Date:
September 27, 1999
Export Citation:
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Assignee:
VARIAN INC (US)
International Classes:
G01N27/62; G01N30/72; H01J49/04; H01J49/10
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