Title:
MULTIPLEX IMMUNOASSAYS FOR HEMOGLOBIN, HEMOGLOBIN VARIANTS, AND GLYCATED FORMS
Document Type and Number:
WIPO Patent Application WO/2011/062803
Kind Code:
A3
Abstract:
Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbAI c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.
Inventors:
WALKER ROGER (US)
JARDIN BENEDICTE (FR)
JARDIN BENEDICTE (FR)
Application Number:
PCT/US2010/055952
Publication Date:
July 28, 2011
Filing Date:
November 09, 2010
Export Citation:
Assignee:
BIO RAD LABORATORIES (US)
WALKER ROGER (US)
JARDIN BENEDICTE (FR)
WALKER ROGER (US)
JARDIN BENEDICTE (FR)
International Classes:
G01N33/53
Foreign References:
| US20040229284A1 | 2004-11-18 | |||
| US5478754A | 1995-12-26 | |||
| US20050158866A1 | 2005-07-21 | |||
| US20040214243A1 | 2004-10-28 |
Other References:
PAPAYANNOPOULOU ET AL.: "Use of specific fluorescent antibodies for the identification of hemoglobin C in erythrocytes.", AM. J. HEMATOL., vol. 2, no. 2, 1977, pages 105 - 112, XP008158699
DELAHUNTY.: "Convenient screening for hemoglobin variants by using the Diamat HPLC system.", CLIN. CHEM., vol. 36, no. 6, 1990, pages 903 - 905, XP008158700
ELBAGGARI ET AL., EVALUATION OF THE CRITERION STAIN FREE GEL IMAGING SYSTEM FOR USE IN WESTERN BLOTTING APPLICATIONS., 2008, XP008158712, Retrieved from the Internet [retrieved on 20110507]
DELAHUNTY.: "Convenient screening for hemoglobin variants by using the Diamat HPLC system.", CLIN. CHEM., vol. 36, no. 6, 1990, pages 903 - 905, XP008158700
ELBAGGARI ET AL., EVALUATION OF THE CRITERION STAIN FREE GEL IMAGING SYSTEM FOR USE IN WESTERN BLOTTING APPLICATIONS., 2008, XP008158712, Retrieved from the Internet
Attorney, Agent or Firm:
HEINES, M. Henry et al. (Two Embarcadero Center 8th Floo, San Francisco California, US)
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