Title:
MULTIPLEX MRM ASSAY FOR EVALUATION OF CANCER
Document Type and Number:
WIPO Patent Application WO/2013/044265
Kind Code:
A3
Abstract:
The current disclosure provides specific peptides, and derived ionization characteristics of the peptides from the estrogen receptor (ER) proteins that are particularly advantageous for quantifying the ER proteins directly in biological samples that have been fixed in formalin by the method of Selected Reaction Monitoring / Multiple Reaction Monitoring (SRM/MRM) mass spectrometry. These peptides can be quantitated if they reside in a modified or in an unmodified form. An example of a modified form of an ER peptide is phosphorylation of a tyrosine, threonine, serine, and/or other amino acid residues within the peptide sequence.
Inventors:
KRIZMAN DAVID B (US)
HEMBROUGH TODD (US)
THYPARAMBIL SHEENO (US)
LIAO WEI-LIAO (US)
HEMBROUGH TODD (US)
THYPARAMBIL SHEENO (US)
LIAO WEI-LIAO (US)
Application Number:
PCT/US2012/056965
Publication Date:
August 29, 2013
Filing Date:
September 24, 2012
Export Citation:
Assignee:
EXPRESSION PATHOLOGY INC (US)
International Classes:
C40B30/10; C07K1/00; C07K14/00
Domestic Patent References:
| WO2011028960A1 | 2011-03-10 |
Foreign References:
| US20110178273A1 | 2011-07-21 | |||
| US20090136971A1 | 2009-05-28 | |||
| US7588887B2 | 2009-09-15 |
Other References:
MUKAI ET AL.: "Rapid modulation of long-term depression and spinogenesis via synaptic estrogen receptors in hippocampal principal neurons", JOURNAL OF NEUROCHEMISTRY, vol. 100, no. 4, February 2007 (2007-02-01), pages 950 - 967, XP055148930
HARVEY ET AL.: "Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand- Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 5, May 1999 (1999-05-01), pages 1474 - 1481, XP008173856
HARVEY ET AL.: "Estrogen Receptor Status by Immunohistochemistry Is Superior to the Ligand- Binding Assay for Predicting Response to Adjuvant Endocrine Therapy in Breast Cancer", JOURNAL OF CLINICAL ONCOLOGY, vol. 17, no. 5, May 1999 (1999-05-01), pages 1474 - 1481, XP008173856
Attorney, Agent or Firm:
BOOTH, Paul, M. (1201 Third AvenueSuite 480, Seattle WA, US)
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