Title:
MULTIPOTENT STEM CELLS FROM PERIPHERAL TISSUES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2003010243
Kind Code:
A3
Abstract:
This invention relates to multipotent stem cells, purified from the peripheral tissue of mammals, and capable of differentiating into neural and non-neural cell types. These stem cells provide an accessible source for autologous transplantation into CNS, PNS, and other damaged tissues.
Inventors:
TOMA JEAN (CA)
AKHAVAN MAHNAZ (CA)
FERNANDES KARL J L (CA)
FORTIER MATHIEU (CA)
MILLER FREDA (CA)
AKHAVAN MAHNAZ (CA)
FERNANDES KARL J L (CA)
FORTIER MATHIEU (CA)
MILLER FREDA (CA)
Application Number:
PCT/CA2002/001130
Publication Date:
July 31, 2003
Filing Date:
July 26, 2002
Export Citation:
Assignee:
UNIV MCGILL (CA)
TOMA JEAN (CA)
AKHAVAN MAHNAZ (CA)
FERNANDES KARL J L (CA)
FORTIER MATHIEU (CA)
MILLER FREDA (CA)
TOMA JEAN (CA)
AKHAVAN MAHNAZ (CA)
FERNANDES KARL J L (CA)
FORTIER MATHIEU (CA)
MILLER FREDA (CA)
International Classes:
A61P25/00; C12N15/09; A61P25/14; A61P25/16; A61P25/28; A61P43/00; C12N5/02; C12N5/074; C12N5/079; C12N5/0793; C12N5/0797; C12N5/10; A61K35/12; (IPC1-7): C12N5/08; A61K35/12
Domestic Patent References:
| WO1997041208A1 | 1997-11-06 | |||
| WO1999056759A1 | 1999-11-11 | |||
| WO2001053461A1 | 2001-07-26 |
Foreign References:
| US20020016002A1 | 2002-02-07 |
Other References:
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, TOMA J G ET AL: "Skin tissue: a source for multipotent neural stem cells.", XP002234778, Database accession no. PREV200100088068
HUARD J M T ET AL: "ADULT OLFACTORY EPITHELIUM CONTAINS MULTIPOTENT PROGENITORS THAT GIVE RISE TO NEURONS AND NON-NEURAL CELLS", JOURNAL OF COMPARATIVE NEUROLOGY, XX, XX, vol. 400, no. 4, 2 November 1998 (1998-11-02), pages 469 - 486, XP001000796
TOMA J G ET AL: "ISOLATION OF MULTIPOTENT ADULT STEM CELLS FROM THE DERMIS OF MAMMALIAN SKIN", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 3, September 2001 (2001-09-01), pages 778 - 784,1, XP001022251, ISSN: 1465-7392
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2001, TOMA J G ET AL: "Identification and transplantation of a novel, multipotent neural stem cell from mammalian skin.", XP002234775, Database accession no. PREV200100486589
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2001, FERNANDES K J L ET AL: "Skin-derived stem cells differentiate into multiple neural and non-neural cell types.", XP002234776, Database accession no. PREV200100486588
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2001, OYELESE A A ET AL: "Neural trans-differentiation of plastic adherent and non-adherent bone marrow stem cells.", XP002234777, Database accession no. PREV200100486851
HUARD J M T ET AL: "ADULT OLFACTORY EPITHELIUM CONTAINS MULTIPOTENT PROGENITORS THAT GIVE RISE TO NEURONS AND NON-NEURAL CELLS", JOURNAL OF COMPARATIVE NEUROLOGY, XX, XX, vol. 400, no. 4, 2 November 1998 (1998-11-02), pages 469 - 486, XP001000796
TOMA J G ET AL: "ISOLATION OF MULTIPOTENT ADULT STEM CELLS FROM THE DERMIS OF MAMMALIAN SKIN", NATURE CELL BIOLOGY, MACMILLAN PUBLISHERS, GB, vol. 3, September 2001 (2001-09-01), pages 778 - 784,1, XP001022251, ISSN: 1465-7392
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2001, TOMA J G ET AL: "Identification and transplantation of a novel, multipotent neural stem cell from mammalian skin.", XP002234775, Database accession no. PREV200100486589
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2001, FERNANDES K J L ET AL: "Skin-derived stem cells differentiate into multiple neural and non-neural cell types.", XP002234776, Database accession no. PREV200100486588
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2001, OYELESE A A ET AL: "Neural trans-differentiation of plastic adherent and non-adherent bone marrow stem cells.", XP002234777, Database accession no. PREV200100486851
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