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Title:
MULTIPURPOSE LINKER COMPOUNDS AND LIGANDS AND PROCESS FOR PRODUCING THE SAME
Document Type and Number:
WIPO Patent Application WO/2004/022565
Kind Code:
A1
Abstract:
A multipurpose linker compound having a structure represented by the following general formula (1): (1) wherein Y has a structure represented by O or NH. In the above formula, X has a multibranched site structure involving 4 hydrocarbon derivative chains each having an aromatic amino group at the end and optionally having a carbon-nitrogen bond in the main chain. This multipurpose linker compound makes it possible to two-dimensionally align saccharide molecules at a high reproducibility on the surface of a support for protein analysis. A ligand in which saccharide molecules have been introduced into the above-described multipurpose linker compound.

Inventors:
Suda, Yasuo (1-13-1-106, Shimoishiki Kagoshima-shi, Kagoshima, 890-0005, JP)
Arano, Akio (1-15-11-801, Toso Kagoshima-shi, Kagoshima, 890-0081, JP)
Hayashi, Hideki (E-310, 463-30 Kagasuno, Kawauchi-ch, Tokushima-shi Tokushima, 771-0130, JP)
Kusumoto, Shoichi (C-114, 3-5 Hanjy, Minoo-shi Osaka, 562-0044, JP)
Sobel, Michael (1624, Peach Court East Seattle, WA, 98112, US)
Application Number:
PCT/JP2003/009973
Publication Date:
March 18, 2004
Filing Date:
August 06, 2003
Export Citation:
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Assignee:
JAPAN SCIENCE AND TECHNOLOGY AGENCY (1-8 Hon-cho 4-chome, Kawaguchi-shi, Saitama, 332-0012, JP)
NATIONAL UNIVERSITY CORPORATION KAGOSHIMA UNIVERSITY (1-21-24, Korimoto Kagoshima-shi, Kagoshima, 890-8580, JP)
Suda, Yasuo (1-13-1-106, Shimoishiki Kagoshima-shi, Kagoshima, 890-0005, JP)
Arano, Akio (1-15-11-801, Toso Kagoshima-shi, Kagoshima, 890-0081, JP)
Hayashi, Hideki (E-310, 463-30 Kagasuno, Kawauchi-ch, Tokushima-shi Tokushima, 771-0130, JP)
Kusumoto, Shoichi (C-114, 3-5 Hanjy, Minoo-shi Osaka, 562-0044, JP)
Sobel, Michael (1624, Peach Court East Seattle, WA, 98112, US)
International Classes:
G01N33/53; C07D495/04; C07H15/04; C07H15/203; G01N21/27; G01N33/531; G01N33/543; (IPC1-7): C07D495/04; C07H15/203; G01N33/53; G01N33/566
Domestic Patent References:
1996-06-13
Foreign References:
JP2003083969A2003-03-19
JPH07252288A1995-10-03
JP2002080488A2002-03-19
Other References:
HAYASHI KUSUMOTO ET AL.: 'Taki yotogata linker o mochiita tosa no shugoka to hyomen plasmon kyomeiho kaiseki narabi ni affinity chromatography eno oyo' THE CHEMICAL SOCIETY OF JAPAN YOKOSHU (2 G2-48) vol. 83, no. 2, 03 March 2003, page 952, XP002975650
HAYASHI KUSUMOTO ET AL.: 'Tosa no shugoka to koteika no tame no shinki linker bunshi no gosei' THE CHEMICAL SOCIETY OF JAPAN KOENYOKOSHU (1 C1-12) vol. 82, 10 September 2002, page 137, XP002975651
HAYSHI ARANO ET AL.: 'Ryusanka oligo-to no shugoka, biotin-ka oyobi sono hyomen plasmon kyomei eno oyo' THE CHEMICAL SOCIETY OF JAPAN YOKOSHU (4G304) vol. 79, no. 2, 2001, page 1042, XP002975652
FUKASE K. ET AL.: 'Functional fluorescence labeling of carbohydrates and its use for preparation of neoglycoconjugates' J. CARBOHYDRATE CHEMISTRY vol. 13, no. 5, 1994, pages 715 - 736, XP002975653
LINDHORST T.K. ET AL.: 'Glycocoating of oligovalent amines: synthesis of thiourea-bridged cluster glycosides from glycosyl isothiocyanates' ANGEWANDTE CHEMIE, INTERNATIONAL EDITION IN ENGLISH vol. 35, no. 17, 1996, pages 1953 - 1956, XP002042915
WELLS N.J. ET AL.: 'Solid-phase dendrimer synthesis' BIOPOLYMERS vol. 47, no. 5, 1999, pages 381 - 396, XP002975654
None
See also references of EP 1548016A1
Attorney, Agent or Firm:
Hara, Kenzo (HARAKENZO PATENT LAW FIRM, Daiwa Minamimorimachi Building 2-6, Tenjinbashi 2-chome Kita, Kita-k, Osaka-shi Osaka, 530-0041, JP)
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