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Title:
MULTISPECIFIC BINDING MOLECULES HAVING SPECIFICITY TO DYSTROGLYCAN AND LAMININ-2
Document Type and Number:
WIPO Patent Application WO/2018/151841
Kind Code:
A8
Abstract:
Provided herein multispecific (e.g., bispecific) binding molecules comprising a first binding domain that binds an extracellular portion of dystroglycan and a second binding domain that binds laminin-2. Further provided herein are methods for making such binding molecules and uses of such binding molecules for treating and/or preventing alpha-dystroglycanopathies.

Inventors:
SEVIGNY, Leila (55 Corporate Drive Mail Code: 55A-505, Bridgewater NJ, 08807, US)
BEIL, Christian (Frankfurt am Main, Main, DE)
BRONDYK, William, H. (55 Corporate Drive Mail Code: 55A-505, Bridgewater NJ, 08807, US)
CHEN, Yangde (3 Hodges Avenue, Wellesley, MA, 02482, US)
CHENG, Seng, H. (55 Corporate Drive Mail Code: 55A-505, Bridgewater NJ, 08807, US)
CONNORS, Timothy, D. (55 Corporate Drive Mail Code: 55A-505, Bridgewater NJ, 08807, US)
DEVAUD, Catherine (1 Avenue Pierre Brossolette, Chilly-Mazarin, Chilly-Mazarin, FR)
HOFFMANN, Dietmar (54 Rue La Boétie, Paris, Paris, FR)
LANGE, Christian (Frankfurt am Main, Main, DE)
MAGNAY, Maureen (55 Corporate Drive Mail Code: 55A-505, Bridgewater NJ, 08807, US)
MAGNAY, Tristan (55 Corporate Drive Mail Code: 55A-505, Bridgewater NJ, 08807, US)
PRADES, Catherine (1 Avenue Pierre Brossolette, Chilly-Mazarin, Chilly-Mazarin, FR)
RAO, Ercole (Frankfurt am Main, Main, DE)
WEI, Ronnie (120 Central Avenue, Needham, MA, 02494, US)
ZHAO, Hongmei (55 Corporate Drive Mail Code:55A-505, Bridgewater NJ, 08807, US)
ZHU, Yunxiang (55 Corporate Drive Mail Code:55A-505, Bridgewater NJ, 08807, US)
Application Number:
US2018/000056
Publication Date:
June 20, 2019
Filing Date:
February 16, 2018
Export Citation:
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Assignee:
SANOFI (54 Rue La Boétie, Paris, Paris, Paris, FR)
SEVIGNY, Leila (55 Corporate Drive Mail Code: 55A-505, Bridgewater NJ, 08807, US)
International Classes:
C07K16/18; A61K39/395; A61P21/00; C07K16/28
Attorney, Agent or Firm:
JONES, Kevin et al. (Morrison & Foerster LLP, 425 Market StreetSan Francisco, CA, 94105-2482, US)
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