Title:
MULTISPECIFIC CONSTRUCTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/051752
Kind Code:
A1
Abstract:
Provided are bispecific and multi-specific antibodies that include an agonist anti-4-1BB single-domain antibody capable of effector function-mediated tumor inhibition. In addition, these agonist antibodies, in the absence of tumor antigen-expressing cells, bind to 4-1BB but are unable to activate 4-1BB signaling. In the presence of a tumor antigen-expressing cell, however, these antibodies can trigger tumor antigen-dependent 4-1BB signaling, leading to potent immune response to the tumor antigen-expressing tumor cells.
Inventors:
CHEN XI (CN)
LI JIAN (CN)
WANG ZHENGYI (CN)
LI JIAN (CN)
WANG ZHENGYI (CN)
Application Number:
PCT/CN2023/117317
Publication Date:
March 14, 2024
Filing Date:
September 06, 2023
Export Citation:
Assignee:
I MAB BIOPHARMA CO LTD (CN)
International Classes:
C07K16/46; A61K39/395; A61P35/00; C07K16/28; C12N5/10; C12N15/13; C12N15/63
Domestic Patent References:
| WO2017182672A1 | 2017-10-26 | |||
| WO2022057871A1 | 2022-03-24 | |||
| WO2020073131A1 | 2020-04-16 |
Foreign References:
| CN112646031A | 2021-04-13 | |||
| AU2017331363A1 | 2019-04-11 | |||
| US20210107982A1 | 2021-04-15 | |||
| US20200399371A1 | 2020-12-24 | |||
| US20210238299A1 | 2021-08-05 |
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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