Title:
MULTISPECIFIC NANOPARTICLE
Document Type and Number:
WIPO Patent Application WO/2023/204290
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a new acellular preparation that need not be prepared for each patient individually and can stably and inexpensively achieve a high killing effect on tumor cells. Provided is a multispecific nanoparticle capable of binding with two or more target cells, wherein the multispecific nanoparticle contains: (1) a lipid membrane constituting the surface layer of the nanoparticle; and (2) (i) a fusion protein including a membrane-binding region bound to the lipid membrane and two or more target binding regions located outside the lipid membrane, or (ii) two or more fusion proteins including a membrane-binding region bound to the lipid membrane and a target binding region located outside the lipid membrane.
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Inventors:
KAGOYA YUKI (JP)
ITO YUSUKE (JP)
OHTA SEIICHI (JP)
ITO YUSUKE (JP)
OHTA SEIICHI (JP)
Application Number:
PCT/JP2023/015857
Publication Date:
October 26, 2023
Filing Date:
April 21, 2023
Export Citation:
Assignee:
AICHI PREFECTURE (JP)
UNIV TOKYO (JP)
UNIV TOKYO (JP)
International Classes:
A61K9/14; C12N15/62; A61K39/395; A61K45/00; A61K47/34; A61K47/69; A61P35/00; C07K14/11; C07K14/705; C07K16/28; C07K16/30; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/13; C12P21/02
Domestic Patent References:
| WO2009020093A1 | 2009-02-12 | |||
| WO2021224499A1 | 2021-11-11 | |||
| WO2021155380A1 | 2021-08-05 | |||
| WO2020071554A1 | 2020-04-09 |
Foreign References:
| JP2020533360A | 2020-11-19 | |||
| JP2016514676A | 2016-05-23 | |||
| JP2022511382A | 2022-01-31 | |||
| JP2019512272A | 2019-05-16 | |||
| JP2018522825A | 2018-08-16 |
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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