Title:
MULTIVALENT ANTIGEN-BINDING PROTEINS
Document Type and Number:
WIPO Patent Application WO1999023221
Kind Code:
A3
Abstract:
A multivalent antigen binding protein comprises a single polypeptide chain comprising, in series, two or more single domain binding units which are preferably heavy chain variable domains derived from an immunoglobulin naturally devoid of light chains. Methods for their production and uses thereof, in particular for diagnosis, immunoassay and purification methods are disclosed.
Inventors:
FRENKEN LEON GERARDUS JOSEPH (NL)
HOWELL STEVEN (GB)
LEDEBOER ADRIANUS MARINUS (NL)
LOGT CORNELIS PAUL ERI VAN DER (GB)
HOWELL STEVEN (GB)
LEDEBOER ADRIANUS MARINUS (NL)
LOGT CORNELIS PAUL ERI VAN DER (GB)
Application Number:
PCT/EP1998/006991
Publication Date:
October 07, 1999
Filing Date:
October 27, 1998
Export Citation:
Assignee:
UNILEVER PLC (GB)
UNILEVER NV (NL)
FRENKEN LEON GERARDUS JOSEPH (NL)
HOWELL STEVEN (GB)
LEDEBOER ADRIANUS MARINUS (NL)
LOGT CORNELIS PAUL ERI VAN DER (GB)
UNILEVER NV (NL)
FRENKEN LEON GERARDUS JOSEPH (NL)
HOWELL STEVEN (GB)
LEDEBOER ADRIANUS MARINUS (NL)
LOGT CORNELIS PAUL ERI VAN DER (GB)
International Classes:
A61K39/395; C07K16/00; C07K16/12; C07K16/26; C07K16/44; C07K16/46; C07K19/00; C12N1/15; C12N15/13; C12N15/62; G01N33/531; G01N33/577; A61K38/00; (IPC1-7): C12N15/13; C07K16/00; C07K16/46; C07K19/00; C12N15/62; C12N1/15; A61K39/395; G01N33/577
Domestic Patent References:
| WO1993011161A1 | 1993-06-10 | |||
| WO1994013806A1 | 1994-06-23 | |||
| WO1997038102A1 | 1997-10-16 | |||
| WO1994025591A1 | 1994-11-10 |
Foreign References:
| EP0368684A1 | 1990-05-16 |
Other References:
M. ARBABI-GHAHROUDI ET AL.: "Selection and identification of single domain antibody fragments from camel heavy-chain antibodies.", FEBS LETTERS, vol. 414, 15 September 1997 (1997-09-15), Amsterdam, The Netherlands, pages 521 - 526, XP002069903
H. HOOGENBOOM: "Mix and match: Building manifold binding sites.", NATURE BIOTECHNOLOGY, vol. 15, no. 2, February 1997 (1997-02-01), New York, NY, USA, pages 125 - 126, XP002110046
D. NERI ET AL.: "High-affinity antigen binding by chelating recombinant antibodies (CRAbs).", JOURNAL OF MOLECULAR BIOLOGY, vol. 246, 1995, Oxford, GB, pages 367 - 373, XP002092191
C. ILL ET AL.: "Design and construction of a hybrid immunoglobulin domain with properties of both heavy and light chain variable regions.", PROTEIN ENGINEERING, vol. 10, no. 8, August 1997 (1997-08-01), Oxford, GB, pages 949 - 957, XP002110047
H. HOOGENBOOM: "Mix and match: Building manifold binding sites.", NATURE BIOTECHNOLOGY, vol. 15, no. 2, February 1997 (1997-02-01), New York, NY, USA, pages 125 - 126, XP002110046
D. NERI ET AL.: "High-affinity antigen binding by chelating recombinant antibodies (CRAbs).", JOURNAL OF MOLECULAR BIOLOGY, vol. 246, 1995, Oxford, GB, pages 367 - 373, XP002092191
C. ILL ET AL.: "Design and construction of a hybrid immunoglobulin domain with properties of both heavy and light chain variable regions.", PROTEIN ENGINEERING, vol. 10, no. 8, August 1997 (1997-08-01), Oxford, GB, pages 949 - 957, XP002110047
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