Title:
MULTIVALENT AND MULTISPECIFIC DR5-BINDING FUSION PROTEINS
Document Type and Number:
WIPO Patent Application WO/2017/011837
Kind Code:
A3
Abstract:
The disclosure relates generally to molecules that specifically engage death receptor 5 (DR5), a member of the TNF receptor superfamily (TNFRSF). More specifically the disclosure relates to multivalent and multispecific molecules that bind at least DR5.
Inventors:
TIMMER JOHN C (US)
JONES KYLE S (US)
RAZAI AMIR S (US)
HUSSAIN ABRAHIM (US)
WILLIS KATELYN M (US)
DEVERAUX QUINN (US)
ECKELMAN BRENDAN P (US)
JONES KYLE S (US)
RAZAI AMIR S (US)
HUSSAIN ABRAHIM (US)
WILLIS KATELYN M (US)
DEVERAUX QUINN (US)
ECKELMAN BRENDAN P (US)
Application Number:
PCT/US2016/042862
Publication Date:
March 02, 2017
Filing Date:
July 18, 2016
Export Citation:
Assignee:
INHIBRX LP (US)
TIMMER JOHN C (US)
JONES KYLE S (US)
RAZAI AMIR S (US)
HUSSAIN ABRAHIM (US)
WILLIS KATELYN M (US)
DEVERAUX QUINN (US)
ECKELMAN BRENDAN P (US)
TIMMER JOHN C (US)
JONES KYLE S (US)
RAZAI AMIR S (US)
HUSSAIN ABRAHIM (US)
WILLIS KATELYN M (US)
DEVERAUX QUINN (US)
ECKELMAN BRENDAN P (US)
International Classes:
C07K16/28
Domestic Patent References:
| WO2012041800A1 | 2012-04-05 |
Foreign References:
| US20150139997A1 | 2015-05-21 | |||
| US5955358A | 1999-09-21 | |||
| US20140227259A1 | 2014-08-14 | |||
| US20110166076A1 | 2011-07-07 | |||
| US20130095109A1 | 2013-04-18 | |||
| US20020147140A1 | 2002-10-10 | |||
| US20110182897A1 | 2011-07-28 |
Other References:
DE MIGUEL ET AL.: "Liposome-bound TRAIL induces superior DR5 clustering and enhanced DISC recruitment in histiocytic lymphoma U937 cells.", LEUK RES., vol. 39, no. 6, pages 657 - 666, XP029177924
Attorney, Agent or Firm:
KARNAKIS, Jennifer A. et al. (US)
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