Title:
MULTIVALENT PNEUMOCOCCAL POLYSACCHARIDE-PROTEIN CONJUGATE COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2014/092378
Kind Code:
A1
Abstract:
Disclosed is an immunogenic composition having 13 different polysaccharide-protein conjugates. Each conjugate contains a capsular polysaccharide which is prepared from different serotypes of streptococcus pneumonia conjugated to a carrier protein, in particular 12 serotypes selected from the group consisting of serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F, and serotypes 22F or 33F. The immunogenic composition formulated as a vaccine having an aluminum-based adjuvant increases coverage against pneumococcal disease in infants and young children.
Inventors:
PARK MAHN-HOON (KR)
KIM HUN (KR)
YANG JI-HYE (KR)
YANG SEON-YOUNG (KR)
NOH MYEONG-JU (KR)
PARK SU-JIN (KR)
SHIN JIN-HWAN (KR)
KIM HUN (KR)
YANG JI-HYE (KR)
YANG SEON-YOUNG (KR)
NOH MYEONG-JU (KR)
PARK SU-JIN (KR)
SHIN JIN-HWAN (KR)
Application Number:
PCT/KR2013/011195
Publication Date:
June 19, 2014
Filing Date:
December 05, 2013
Export Citation:
Assignee:
SK CHEMICALS CO LTD (KR)
International Classes:
A61K47/48; A61K39/39; A61K47/36; A61P37/00
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Other References:
"Mortality Trend by Cause", 2010, THE NATIONAL STATISTICAL OFFICE
HARBOE ZB; BENFIELD TL; VATENTINER-BRANTH P ET AL.: "Temporal Trends in Invasive Pneumococcal Disease and Pneumococcal Serotypes over 7 Decades", CLIN INFECT DIS, vol. 50, 2010, pages 329 - 37
LAURI A. HICKS ET AL.: "Incidence of Pneumococcal Disease Due to Non-Pneumococcal Conjugate Vaccine (PCV7) Serotypes in the United States during the Era of Widespread PCV7 Vaccination, 1998-2004", CLIN INFECT DIS, vol. 196, 2007, pages 1346 - 54
MICHAEL R. JACOBS ET AL.: "Emergence of Streptococcus pneumoniae Serotypes 19A, 6C, and 22F and Serogroup 15 in Cleveland, Ohio, in Relation to Introduction of the Protein-Conjugated Pneumococcal Vaccine, 1998-2004", CLIN INFECT DIS, vol. 47, 2008, pages 1388 - 95
See also references of EP 2932980A4
HARBOE ZB; BENFIELD TL; VATENTINER-BRANTH P ET AL.: "Temporal Trends in Invasive Pneumococcal Disease and Pneumococcal Serotypes over 7 Decades", CLIN INFECT DIS, vol. 50, 2010, pages 329 - 37
LAURI A. HICKS ET AL.: "Incidence of Pneumococcal Disease Due to Non-Pneumococcal Conjugate Vaccine (PCV7) Serotypes in the United States during the Era of Widespread PCV7 Vaccination, 1998-2004", CLIN INFECT DIS, vol. 196, 2007, pages 1346 - 54
MICHAEL R. JACOBS ET AL.: "Emergence of Streptococcus pneumoniae Serotypes 19A, 6C, and 22F and Serogroup 15 in Cleveland, Ohio, in Relation to Introduction of the Protein-Conjugated Pneumococcal Vaccine, 1998-2004", CLIN INFECT DIS, vol. 47, 2008, pages 1388 - 95
See also references of EP 2932980A4
Attorney, Agent or Firm:
OH, KOOK-JIN (KR)
오국진 (KR)
오국진 (KR)
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