Title:
MURAMYL COMPOUNDS FOR TREATMENT OF SEPTIC SHOCK
Document Type and Number:
WIPO Patent Application WO/1993/010148
Kind Code:
A1
Abstract:
Muramyl peptide compounds which: (a) are non-pyrogenic; and/or (b) ameliorate endotoxin-induced weight loss and/or hypophagia; and/or (c) reduce TNF production; and/or (d) stimulate macrophages to process endotoxin are useful, in the treatment of septic shock, cachexia and other life-threatening inflammatory conditions. Preferred compounds include N-acetyl-glucosaminyl-N-acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) and N-acetyl-glucosaminyl-N-acetyl-muramyl-L-alanyl-D-glutamic acid (GMDP-A).
Inventors:
ASTON ROGER (GB)
Application Number:
PCT/GB1992/002137
Publication Date:
May 27, 1993
Filing Date:
November 19, 1992
Export Citation:
Assignee:
BIOKINE TECH LTD (GB)
International Classes:
A61K38/14; A61P9/00; A61K38/00; A61P29/00; C07K5/062; C07K5/083; C07K5/103; C07K7/06; C07K9/00; (IPC1-7): A61K37/02; C07K9/00
Foreign References:
| EP0015810A1 | 1980-09-17 | |||
| EP0331756A1 | 1989-09-13 | |||
| US4382080A | 1983-05-03 |
Other References:
CHEMICAL ABSTRACTS, vol. 110, 1989, Columbus, Ohio, US; abstract no. 149208, KODAMA ET AL 'Medical treatment of endotoxin shock' page 234 ;column 2 ;
CHEMICAL ABSTRACTS, vol. 96, 1982, Columbus, Ohio, US; abstract no. 50259, MATSUMOTO ET AL 'Stimulation of nonspecific host resistance to infection induced by muramyldipeptides' page 441 ;column 1 ;
THE AMERICAN SURGEON vol. 52, no. 11, November 1986, PHILADELPHIA, USA pages 613 - 617 CHEADLE ET AL 'Effects of muramyl dipeptide and lead acetate on carbon clearance and endotoxin-induced mortality in mice'
INFECTION AND IMMUNITY vol. 32, no. 2, May 1981, WASHINGTON, USA pages 748 - 758 MATSUMOTO ET AL 'Stimulation of nonspecific resistance to infection induced by 6-O-acyl-muramyl dipeptide analogs in mice'
EDITORS: HERZ ET AL // AUTHORS: CADBY ET AL 'Progress in the chemistry of organic natural products - 40' 1981 , SPRINGER-VERLAG , WIEN , AUSTRIA
BULL. CHEM. SOC. JAPAN vol. 53, no. 9, 1980, TOKYO, JAPAN pages 2570 - 2577 KOBAYASHI ET AL 'Synthesis of muramyl dipetide analogs with enhanced adjuvant activity'
VOLUME EDITOR: EMMETT,JOHN C. 'Comprehensive Medicinal Chemistry, Volume 3 , Membranes & Receptors' 1990 , PERGAMON PRESS , OXFORD, ENGLAND
EXPERIENTIA vol. 42, 1986, BASEL pages 521 - 531 WERNER ET AL 'Immunomodulating peptides'
JOURNAL OF MEDICINAL CHEMISTRY vol. 23, no. 8, 1980, WASHINGTON, USA pages 819 - 825 LEDERER, E 'Synthetic immunostimulants derived from the bacterial cell wall'
INFECTION AND IMMUNITY vol. 59, no. 1, January 1991, WASHINGTON, USA pages 126 - 130 IZBICKI 'Beneficial effect of liposome-encapsulated muramyl tripeptide in experimental septicemia in a porcine model'
CHEMICAL ABSTRACTS, vol. 96, 1982, Columbus, Ohio, US; abstract no. 50259, MATSUMOTO ET AL 'Stimulation of nonspecific host resistance to infection induced by muramyldipeptides' page 441 ;column 1 ;
THE AMERICAN SURGEON vol. 52, no. 11, November 1986, PHILADELPHIA, USA pages 613 - 617 CHEADLE ET AL 'Effects of muramyl dipeptide and lead acetate on carbon clearance and endotoxin-induced mortality in mice'
INFECTION AND IMMUNITY vol. 32, no. 2, May 1981, WASHINGTON, USA pages 748 - 758 MATSUMOTO ET AL 'Stimulation of nonspecific resistance to infection induced by 6-O-acyl-muramyl dipeptide analogs in mice'
EDITORS: HERZ ET AL // AUTHORS: CADBY ET AL 'Progress in the chemistry of organic natural products - 40' 1981 , SPRINGER-VERLAG , WIEN , AUSTRIA
BULL. CHEM. SOC. JAPAN vol. 53, no. 9, 1980, TOKYO, JAPAN pages 2570 - 2577 KOBAYASHI ET AL 'Synthesis of muramyl dipetide analogs with enhanced adjuvant activity'
VOLUME EDITOR: EMMETT,JOHN C. 'Comprehensive Medicinal Chemistry, Volume 3 , Membranes & Receptors' 1990 , PERGAMON PRESS , OXFORD, ENGLAND
EXPERIENTIA vol. 42, 1986, BASEL pages 521 - 531 WERNER ET AL 'Immunomodulating peptides'
JOURNAL OF MEDICINAL CHEMISTRY vol. 23, no. 8, 1980, WASHINGTON, USA pages 819 - 825 LEDERER, E 'Synthetic immunostimulants derived from the bacterial cell wall'
INFECTION AND IMMUNITY vol. 59, no. 1, January 1991, WASHINGTON, USA pages 126 - 130 IZBICKI 'Beneficial effect of liposome-encapsulated muramyl tripeptide in experimental septicemia in a porcine model'
Download PDF:
Previous Patent: NOVEL AMYLIN ANTAGONIST PEPTIDES AND USES THEREFOR
Next Patent: RECOMBINANT MAMMALIAN CALCITONIN RECEPTORS AND USES THEREOF
Next Patent: RECOMBINANT MAMMALIAN CALCITONIN RECEPTORS AND USES THEREOF