Title:
MUSCARINIC RECEPTOR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO1999064043
Kind Code:
A9
Abstract:
Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.
Inventors:
MAMMEN MATHAI (US)
OARE DAVID (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
OARE DAVID (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
Application Number:
PCT/US1999/012733
Publication Date:
March 02, 2000
Filing Date:
June 07, 1999
Export Citation:
Assignee:
ADVANCED MEDICINE INC (US)
MAMMEN MATHAI (US)
OARE DAVID (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
MAMMEN MATHAI (US)
OARE DAVID (US)
GRIFFIN JOHN H (US)
AGGEN JAMES (US)
International Classes:
G01N33/53; A01N43/00; A01N55/02; A61K31/135; A61K31/33; A61K31/40; A61K31/404; A61K31/44; A61K31/4427; A61K31/4439; A61K31/445; A61K31/45; A61K31/4523; A61K31/454; A61K31/4545; A61K31/455; A61K31/498; A61K38/00; A61K38/16; A61K39/00; A61K39/395; A61K39/44; A61K51/00; A61P1/04; A61P1/06; A61P11/00; A61P11/06; A61P13/00; A61P43/00; C07B61/00; C07C217/10; C07D207/08; C07D209/00; C07D209/32; C07D209/48; C07D211/00; C07D211/44; C07D211/46; C07D221/24; C07D401/06; C07D401/12; C07D401/14; C07D403/06; C07D451/00; C07D451/06; C07D451/10; C07D487/18; C07K2/00; C07K4/00; C07K5/02; C40B20/00; C40B40/02; C40B40/04; C40B50/06; C40B60/10; G01N33/543; G01N33/566; (IPC1-7): A61K38/00; A01N43/00; A01N55/02; A61K39/00; A61K39/395; A61K39/44; A61K51/00; C07K2/00; C07K4/00; G01N33/53; G01N33/543; G01N33/566
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