Title:
MUSCLE-BUILDING AGENT, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2014/119634
Kind Code:
A1
Abstract:
The objective of the present invention is to develop and provide a novel muscle-building agent in which a muscle hypertrophy promoter and a muscle atrophy therapeutic agent are active ingredients, which can induce muscle building without exercise, and which has few side effects. For example, provided is a muscle-building agent which contains a P2Y receptor antagonist such as APT and UTP, and which directly or indirectly activates inositol trisphosphate receptors in the sarcoplasmic reticulum membrane, thereby inducing the release of calcium ions from the sarcoplasmic reticulum.
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Inventors:
TAKEDA SHIN ICHI (JP)
ITO NAOKI (JP)
SUZUKI YUKO (JP)
RUEGG URS (JP)
ITO NAOKI (JP)
SUZUKI YUKO (JP)
RUEGG URS (JP)
Application Number:
PCT/JP2014/052016
Publication Date:
August 07, 2014
Filing Date:
January 30, 2014
Export Citation:
Assignee:
NAT CT NEUROLOGY & PSYCHIATRY (JP)
International Classes:
A61K45/00; A61K31/7072; A61K31/7076; A61P21/00; A61P21/06; A61P43/00; C12N15/09
Domestic Patent References:
| WO2005084440A1 | 2005-09-15 | |||
| WO2011098449A1 | 2011-08-18 | |||
| WO2007047112A2 | 2007-04-26 | |||
| WO2007044411A2 | 2007-04-19 |
Other References:
NAKAHARA, M.: "Progressive muscular dystrophy. I. Effects of adenosine triphosphate and its related compounds on progressive muscular dystrophy", ARZNEIMITTEL-FORSCHUNG, vol. 15, no. 6, 1965, pages 591 - 595
MASAO NAKAHARA ET AL.: "Zenkecchu ni Okeru ATP, UTP Oyobi ITP no Bunkai ni Tsuite", SOGO IGAKU, vol. 20, no. 9, 1963, pages 679 - 682
MASAO NAKAHARA: "Shinkosei dystrophy no ATP Ryoho", SEIKEI GEKA, vol. 16, no. 4, 1965, pages 299 - 318
KOBIELOWA, Z. ET AL.: "Clinical studies and attempted ATP therapy of progressive muscular dystrophy in children.", NEUROLOGIA, NEUROCHIRURGIA I PSYCHIATRIA POLSKA, vol. 11, no. 6, 1961, pages 803 - 809
STELGENS, P.: "Über die Behandlung der Dystrophia musculorum progressiva (Erb) mit Adenosintriphosphorsaure", DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, vol. 82, no. 41, 1957, pages 1761 - 1763
RYTEN, M. ET AL.: "Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures", FASEB JOURNAL, vol. 18, no. 10, 2004, Retrieved from the Internet [retrieved on 20140422]
IQBAL, T. R. ET AL.: "Signal transduction pathways of IP3R3-containing microvillous cells", CHEMICAL SENSES, vol. 36, no. 9, 2011, pages A97 - A98
ORELLANA, J. A. ET AL.: "Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels", GLIA, vol. 60, no. 1, 2012, pages 53 - 68
MASAO NAKAHARA ET AL.: "Zenkecchu ni Okeru ATP, UTP Oyobi ITP no Bunkai ni Tsuite", SOGO IGAKU, vol. 20, no. 9, 1963, pages 679 - 682
MASAO NAKAHARA: "Shinkosei dystrophy no ATP Ryoho", SEIKEI GEKA, vol. 16, no. 4, 1965, pages 299 - 318
KOBIELOWA, Z. ET AL.: "Clinical studies and attempted ATP therapy of progressive muscular dystrophy in children.", NEUROLOGIA, NEUROCHIRURGIA I PSYCHIATRIA POLSKA, vol. 11, no. 6, 1961, pages 803 - 809
STELGENS, P.: "Über die Behandlung der Dystrophia musculorum progressiva (Erb) mit Adenosintriphosphorsaure", DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, vol. 82, no. 41, 1957, pages 1761 - 1763
RYTEN, M. ET AL.: "Purinoceptor expression in regenerating skeletal muscle in the mdx mouse model of muscular dystrophy and in satellite cell cultures", FASEB JOURNAL, vol. 18, no. 10, 2004, Retrieved from the Internet
IQBAL, T. R. ET AL.: "Signal transduction pathways of IP3R3-containing microvillous cells", CHEMICAL SENSES, vol. 36, no. 9, 2011, pages A97 - A98
ORELLANA, J. A. ET AL.: "Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels", GLIA, vol. 60, no. 1, 2012, pages 53 - 68
Attorney, Agent or Firm:
HIRAKI Yusuke et al. (JP)
Yusuke Hiraki (JP)
Yusuke Hiraki (JP)
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