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Title:
MUSCLE DIFFERENTIATION PROMOTER, MUSCLE DIFFERENTIATION PROMOTION METHOD, MUSCLE-DIFFERENTIATION-PROMOTING OLIGO DNA, ENHANCER, AND OLIGO DNA
Document Type and Number:
WIPO Patent Application WO/2018/151225
Kind Code:
A1
Abstract:
The muscle differentiation promoter according to the present invention includes oligo DNA having activity to promote muscle differentiation by being applied to cells or to an individual. The oligo DNA preferably includes a core base sequence represented by 5'TTAGGG3' or 5'TGAGGG3' and has a base sequence AGA or a base sequence AAG on the 5' end side. Berberine or an analogous compound thereof or a salt thereof may be included in addition to the oligo DNA.

Inventors:
TAKAYA TOMOHIDE (JP)
SHIMOSATO TAKESHI (JP)
UMEZAWA KOJI (JP)
Application Number:
PCT/JP2018/005305
Publication Date:
August 23, 2018
Filing Date:
February 15, 2018
Export Citation:
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Assignee:
UNIV SHINSHU (JP)
International Classes:
A61K31/711; A61K31/4738; A61K48/00; A61P21/00; A61P43/00; C12N5/077; C12N15/11; C12N15/113
Domestic Patent References:
WO2008151022A22008-12-11
WO2005086595A22005-09-22
Foreign References:
CN102260699A2011-11-30
Other References:
TOMLINSON C. G. ET AL.: "Quantitative assays for measuring human telomerase activity and DNA binding properties", METHODS, vol. 114, 6 August 2016 (2016-08-06), pages 85 - 95, XP029886619
SUN PANPAN ET AL.: "DNA-fueled molecular machine for label-free and non-enzymatic ultrasensitive detection of telomerase activity", ANALYST, vol. The Anal, 2016, pages 4855 - 4858, XP055537351
WILKING MICHAEL ET AL.: "The influence of G-quadruplex structure on DNA-based asymmetric catalysis using the G-quadruplex-bound cationic porphyrin TMPyP4.Cu", ORGANIC AND BIOMOLECULAR CHEMISTRY, vol. 11, no. 40, 2013, pages 6940 - 6945, XP055537354
SHINJI, SAYAKA ET AL.: "Searching for lactobacillus -derived oligo DNA which is applied to skeletal muscle stem cell differentiation", 122TH ANNUAL MEETING OF JAPANESE SOCIETY OF ANIMAL SCIENCE, vol. 122, March 2017 (2017-03-01), pages 192
SHINJI, SAYAKA ET AL.: "Abstrac P.45 Skeletal muscle differentation induction by complex of lactobacillus oligo DNA and crude drugs", JSBBA, vol. 180, pages 27, Retrieved from the Internet
FUTAHASHI, YUMA ET AL: "Abstrac: VII06-10. Differentiation induction of chicken moblast cell by lactobacillus-derived oligo DNA", 123TH ANNUAL MEETING OF JAPANESE SOCIETY OF ANIMAL SCIENCE, 6 September 2017 (2017-09-06), pages 117
SHINJI, SAYAKA ET AL.: "Abstrac: VII06-11. Proliferation inhibition of human rhabdomyosarcoma by lactobacillus oligo DNA wich promotes myogenesis", 122TH ANNUAL MEETING OF JAPANESE SOCIETY OF ANIMAL SCIENCE, 6 September 2017 (2017-09-06), pages 117
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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