Title:
MUSCLE RELAXANT
Document Type and Number:
WIPO Patent Application WO/2023/190897
Kind Code:
A1
Abstract:
The present invention provides a discovery of a new compound that can be used as a muscle relaxant. Specifically, the present invention provides a compound represented by general formula (I) or a pharmacologically acceptable salt thereof. In general formula (I), X1, X2, X3, and X4 each independently represent hydrogen or an alkoxy group having 1-3 carbon atoms, at least two of X1, X2, X3, and X4 each represent an alkoxy group having 1-3 carbon atoms, Y1, Y2, Y3, Y4, and Y5 each independently represent hydrogen or an alkoxy group having 1-3 carbon atoms, at least two of Y1, Y2, Y3, Y4, and Y5 each represent an alkoxy group having 1-3 carbon atoms, n represents 0 or 1, and L represents a linker having 5-20 atoms in the main chain.
Inventors:
SUNAGA HIROSHI (JP)
Application Number:
PCT/JP2023/013247
Publication Date:
October 05, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
SUNAGA HIROSHI (JP)
International Classes:
A61K31/472; C07D217/24; A61P21/02
Domestic Patent References:
| WO2021115413A1 | 2021-06-17 |
Foreign References:
| CN111662230A | 2020-09-15 |
Other References:
GLADYCH, J. M. Z. ET AL.: "281. Synthetic neuromuscular blocking agents. Part IV. Compounds related to both laudexium and suxamethonium", JOURNAL OF THE CHEMICAL SOCIETY, 1962, pages 1481 - 1487, XP002070649, DOI: 10.1039/jr9620001481
BOROS, ERIC E. ET AL.: "Neuromuscular Blocking Activity and Therapeutic Potential of Mixed- Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 12, 8 May 2003 (2003-05-08), pages 2502 - 2515, XP002324146, DOI: 10.1021/jm020574+
SAMANO, VICENTE ET AL.: "Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates", ORGANIC LETTERS, vol. 1, no. 12, 18 November 1999 (1999-11-18), pages 1993 - 1996, XP055821126, DOI: 10.1021/o19911573
BOROS, ERIC E. ET AL.: "Neuromuscular Blocking Activity and Therapeutic Potential of Mixed- Tetrahydroisoquinolinium Halofumarates and Halosuccinates in Rhesus Monkeys", JOURNAL OF MEDICINAL CHEMISTRY, vol. 46, no. 12, 8 May 2003 (2003-05-08), pages 2502 - 2515, XP002324146, DOI: 10.1021/jm020574+
SAMANO, VICENTE ET AL.: "Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates", ORGANIC LETTERS, vol. 1, no. 12, 18 November 1999 (1999-11-18), pages 1993 - 1996, XP055821126, DOI: 10.1021/o19911573
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
Download PDF: