Title:
MUSCLE-TARGETING COMPLEXES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/142313
Kind Code:
A1
Abstract:
Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In some embodiments, the molecular payload inhibits activity of a disease allele associated with muscle disease. In some embodiments, the molecular payload is an oligonucleotide, such as an antisense oligonucleotide or RNAi oligonucleotide.
Inventors:
SUBRAMANIAN ROMESH (US)
QATANANI MOHAMMED (US)
WEEDEN TIMOTHY (US)
DESJARDINS CODY (US)
QUINN BRENDAN (US)
RHODES JASON (US)
QATANANI MOHAMMED (US)
WEEDEN TIMOTHY (US)
DESJARDINS CODY (US)
QUINN BRENDAN (US)
RHODES JASON (US)
Application Number:
PCT/US2021/012764
Publication Date:
July 15, 2021
Filing Date:
January 08, 2021
Export Citation:
Assignee:
DYNE THERAPEUTICS INC (US)
International Classes:
C07K16/28; A61K39/395; A61P21/00; C12N15/113
Domestic Patent References:
| WO2019113393A1 | 2019-06-13 |
Foreign References:
| US20050084906A1 | 2005-04-21 | |||
| US20140363455A1 | 2014-12-11 |
Other References:
See also references of EP 4087876A4
Attorney, Agent or Firm:
GE, Zhiyun et al. (US)
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