Title:
MUTANT HPPD POLYPEPTIDE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/040917
Kind Code:
A1
Abstract:
Provided are a herbicide-resistant gene, a polypeptide, and an application thereof in plant breeding. Specifically, provided is a mutant HPPD polypeptide, and compared with a parent HPPD polypeptide, the mutant HPPD polypeptide has mutation occurred at any one or more of amino acids corresponding to positions 54, 133, and 401 of SEQ ID NO.1. The mutant HPPD polypeptide is highly tolerant of herbicides, and has a wide application prospect in the field of improving and cultivating plants tolerant of anti-HPPD inhibitory herbicides.
Inventors:
ZHANG JINSHAN (CN)
DONG YINGHUI (CN)
NIU XIAOMU (CN)
LI FENG (CN)
DONG YINGHUI (CN)
NIU XIAOMU (CN)
LI FENG (CN)
Application Number:
PCT/CN2022/118841
Publication Date:
March 23, 2023
Filing Date:
September 14, 2022
Export Citation:
Assignee:
SHANDONG SHUNFENG BIOTECHNOLOGY CO LTD (CN)
International Classes:
A01H1/00; C12N9/02; C12N15/53; C12N15/63
Domestic Patent References:
| WO1999004021A1 | 1999-01-28 |
Foreign References:
| US20200239905A1 | 2020-07-30 | |||
| CN113265401A | 2021-08-17 | |||
| CN101586108A | 2009-11-25 |
Other References:
YANG GUANGFU: "Chemical Biology-Oriented Molecular Design of Green Pesticide", BULLETIN OF NATIONAL NATURAL SCIENCE FOUNDATION OF CHINA, vol. 34, no. 4, 31 December 2020 (2020-12-31), pages 495 - 501, XP093049587, ISSN: 1000-8217, DOI: 10.16262/j.cnki.1000-8217.2020.04.016
HE BO, WANG DAWEI, YANG WENCHAO, CHEN QIONG, YANG GUANGFU: "Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides", CHINESE JOURNAL OF ORGANIC CHEMISTRY, SCIENCE PRESS, BEIJING., CN, vol. 37, no. 11, 1 January 2017 (2017-01-01), CN , pages 2895 - 2904, XP093049949, ISSN: 0253-2786, DOI: 10.6023/cjoc201705031
张玉池等 (ZHANG, YUCHI ET AL.): "国内外抗除草剂基因专利的分析 (Analysis on the Patents of Herbicide Resistance Gene at Home and Abroad)", 杂草学报 (JOURNAL OF WEED SCIENCE), vol. 35, no. 2, 31 December 2017 (2017-12-31)
BRABHAM CHAD, NORSWORTHY JASON K., GONZÁLEZ-TORRALVA FIDEL: "Presence of the HPPD Inhibitor Sensitive 1 Gene and ALSS653N Mutation in Weedy Oryza sativa Sensitive to Benzobicyclon", PLANTS, vol. 9, no. 11, pages 1576, XP093049953, DOI: 10.3390/plants9111576
HUANG, CHIWEI ET AL.: "Functional Role of Residues Involved in Substrate Binding of Human 4-hydroxyphenylpyruvate dioxygenase", BIOCHEMICAL JOURNAL, vol. 478, no. 12, 18 June 2021 (2021-06-18), pages 2201 - 2215, ISSN: 0264-6021
HE BO, WANG DAWEI, YANG WENCHAO, CHEN QIONG, YANG GUANGFU: "Advances in Research on 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Structure and Pyrazole-Containing Herbicides", CHINESE JOURNAL OF ORGANIC CHEMISTRY, SCIENCE PRESS, BEIJING., CN, vol. 37, no. 11, 1 January 2017 (2017-01-01), CN , pages 2895 - 2904, XP093049949, ISSN: 0253-2786, DOI: 10.6023/cjoc201705031
张玉池等 (ZHANG, YUCHI ET AL.): "国内外抗除草剂基因专利的分析 (Analysis on the Patents of Herbicide Resistance Gene at Home and Abroad)", 杂草学报 (JOURNAL OF WEED SCIENCE), vol. 35, no. 2, 31 December 2017 (2017-12-31)
BRABHAM CHAD, NORSWORTHY JASON K., GONZÁLEZ-TORRALVA FIDEL: "Presence of the HPPD Inhibitor Sensitive 1 Gene and ALSS653N Mutation in Weedy Oryza sativa Sensitive to Benzobicyclon", PLANTS, vol. 9, no. 11, pages 1576, XP093049953, DOI: 10.3390/plants9111576
HUANG, CHIWEI ET AL.: "Functional Role of Residues Involved in Substrate Binding of Human 4-hydroxyphenylpyruvate dioxygenase", BIOCHEMICAL JOURNAL, vol. 478, no. 12, 18 June 2021 (2021-06-18), pages 2201 - 2215, ISSN: 0264-6021
Attorney, Agent or Firm:
BEIJING JUNHUI INTELLECTUAL PROPERTY AGENT OFFICE (ORDINARY PARTNERSHIP) (CN)
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