Title:
MUTANT MICROORGANISM HAVING ENHANCED SUCCINIC ACID PRODUCTION CAPACITY AND SUCCINIC ACID PRODUCTION METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2018/212627
Kind Code:
A1
Abstract:
The present invention relates to a mutant microorganism having enhanced succinic acid production capacity and a succinic acid production method using the same. The present invention has the effect of obtaining a mutant microorganism that decreases in the production of fermented products such as lactic acid, ethanol, etc., but produces succinic acid at a high concentration due to the mutation of a transcription regulator factor associated with microbial sugar transport as a result of adaptive evolution upon deletion of a gene involved in the sugar transport in an anaerobic condition and of providing a method in which the obtained mutant microorganism is cultured to produce succinic acid at high yield or with high productivity.
Inventors:
LEE SANG JUN (KR)
KIM HYUN JU (KR)
KIM HYUN JU (KR)
Application Number:
PCT/KR2018/005742
Publication Date:
November 22, 2018
Filing Date:
May 18, 2018
Export Citation:
Assignee:
CHUNG ANG UNIV INDUSTRY ACADEMY COOPERATION FOUNDATION (KR)
International Classes:
C12N15/70; C07K14/245; C12P7/46; C12R1/19
Domestic Patent References:
| WO2011163128A1 | 2011-12-29 |
Foreign References:
| KR20160142057A | 2016-12-12 |
Other References:
STEIN SIEK, SONJA ET AL.: "Glucose Transport in Escherichia Coli Mutant Strains with Defects in Sugar Transport Systems", JOURNAL OF BACTERIOLOGY, vol. 194, no. 21, 2012, pages 5897 - 5908, XP055555654
ROBERT-BAUDOUY, JANINE ET AL.: "Regulation of Hexuronate System Genes in Escherichia Coli K-12: Multiple Regulation of the Uxu Operon by ExuR and UxuR Gene Products", JOURNAL OF BACTERIOLOGY, vol. 145, no. 1, 1981, pages 211 - 220, XP055555660
HU , ZONGLIN ET AL.: "Genetic Analysis of the Roles of AgaA, Agal, and AgaS Genes in the N-acetyl-D-galactosamine and D-galactosamine Catabolic Pathways in Escherichia Coli Strains 0157:H7 and C", BMC MICROBIOLOGY, vol. 13, 2013, pages 1 - 16, XP021150599
ROBERT-BAUDOUY, JANINE ET AL.: "Regulation of Hexuronate System Genes in Escherichia Coli K-12: Multiple Regulation of the Uxu Operon by ExuR and UxuR Gene Products", JOURNAL OF BACTERIOLOGY, vol. 145, no. 1, 1981, pages 211 - 220, XP055555660
HU , ZONGLIN ET AL.: "Genetic Analysis of the Roles of AgaA, Agal, and AgaS Genes in the N-acetyl-D-galactosamine and D-galactosamine Catabolic Pathways in Escherichia Coli Strains 0157:H7 and C", BMC MICROBIOLOGY, vol. 13, 2013, pages 1 - 16, XP021150599
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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