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Title:
MUTANT MICROORGANISM HAVING A HYDROCARBON-GENERATING ABILITY AND METHOD FOR PRODUCING HYDROCARBON USING SAME
Document Type and Number:
WIPO Patent Application WO/2011/155799
Kind Code:
A2
Abstract:
The present invention relates to a mutant microorganism having the ability to generate hydrocarbon containing alkanes and to a method for producing hydrocarbons containing alkanes using the same. More particularly, the present invention relates to a mutant microorganism in which genes that code for enzymes for converting fatty acyl-acps to free fatty acids, genes that code for enzymes for converting free fatty acids to fatty acyl-CoA, genes that code for enzymes for converting fatty acyl-CoA to fatty aldehydes, and genes that code for enzymes for converting fatty aldehydes to alkanes are introduced to the microorganisms improved to be appropriate for the production of hydrocarbons containing alkanes. The present invention also relates to a method for producing hydrocarbons containing alkanes. The mutant microorganism according to the present invention has a high possibility of being utilized in strain improvement resulting from an additional metabolic control, and therefore, can be valuably used in the industrial production of hydrocarbons containing alkanes.

Inventors:
LEE, Sang Yup (212-702, Expo Apt.Jeonmin-dong, Yuseong-gu, Daejeon 305-761, 305-761, KR)
이상엽 (대전광역시 유성구 전민동 엑스포아파트 212동 702호, 305-761 Daejeon, 305-761, KR)
Application Number:
KR2011/004289
Publication Date:
December 15, 2011
Filing Date:
June 10, 2011
Export Citation:
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Assignee:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY (373-1, Guseong-dongYuseong-gu, Daejeon 305-701, 305-701, KR)
한국과학기술원 (대전광역시 유성구 구성동 373-1, 305-701 Daejeon, 305-701, KR)
LEE, Sang Yup (212-702, Expo Apt.Jeonmin-dong, Yuseong-gu, Daejeon 305-761, 305-761, KR)
International Classes:
C12N1/21; C12N15/52; C12P5/00
Other References:
LENNEN, R. M. ET AL.: 'A process for microbial hydrocarbon synthesis: Overproduction of fatty acids in Escherichia coli and catalytic conversion to alkanes' BIOTECHNOL. BIOENG. vol. 106, no. 2, 01 June 2010, pages 193 - 202, XP055003869
YAN, Y. ET AL.: 'Engineering metabolic systems for production of advanced fuels' J. IND. MICROBIOL. BIOTECHNOL. vol. 36, 07 February 2009, pages 471 - 479, XP019665595
KNOLL L.J. ET AL.: 'Use of Escherichia coli strains containing fad mutations plus a triple plasmid expression system to study the import of myristate, its activation by Saccharomyces cerevisiae acyl-Coa synthetase, and its ulilization by S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase' J. BIOL. CHEM. vol. 268, no. 6, 25 February 1993, pages 4281 - 4290, XP055095203
LEE ET AL. BIOPROCESS BIOSYST. ENG. vol. 26, 2003, page 63
LEE ET AL. APPL. MICROBIOL. BIOTECHNOL. vol. 58, 2002, page 663
LEE ET AL. BIOTECHNOL. LETT. vol. 25, 2003, page 111
LEE ET AL. APPL. MICROBIOL. BIOTECHNOL. vol. 54, 2000, page 23
LEE ET AL. BIOTECHNOL. BIOENG. vol. 72, 2001, page 41
WARNER ET AL. PNAS vol. 97, no. 12, 2000, pages 6640 - 6645
ZHI-GANG QIAN ET AL. BIOTECHNOLOGY AND BIOENGINEERING vol. 104, 2009, pages 651 - 654
HISZCZYN; SKA-SAWICKA; KUR PLASMID DIGESTED WITH THE SAME RESTRICTION ENZYMES 1997,
Attorney, Agent or Firm:
LEE, Cheo Young (11th, Yeosam Bldg.648-23, Yeoksam-dong, Gangnam-gu, Seoul 135-080, 135-080, KR)
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