Title:
MUTANT PROTEIN OF GLYCOSYLTRANSFERASE AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/119756
Kind Code:
A1
Abstract:
Provided are a mutant protein of glycosyltransferase and uses thereof. Specifically, by using homology alignment and site-directed mutagenesis, a new mutant protein of glycosyltransferase is discovered. The mutant protein is a non-natural protein with glycosyltransferase catalytic activity, which contains the following core amino acids related to enzyme catalytic activity: the amino acid at position 142 is A, the amino acid at position 144 is H or F and the amino acid at position 339is G, wherein the number of the amino acid position is based on the sequence shown in SEQ ID NO: 13.
Inventors:
ZHOU ZHIHUA (CN)
WEI WEI (CN)
YAN XING (CN)
WANG PINGPING (CN)
WEI YONGJUN (CN)
YANG CHENGSHUAI (CN)
WEI WEI (CN)
YAN XING (CN)
WANG PINGPING (CN)
WEI YONGJUN (CN)
YANG CHENGSHUAI (CN)
Application Number:
PCT/CN2016/073074
Publication Date:
August 04, 2016
Filing Date:
February 01, 2016
Export Citation:
Assignee:
SHANGHAI INST BIOL SCIENCES (CN)
International Classes:
C12N9/10; A01H5/00; C12N1/21; C12N5/10; C12N15/54; C12N15/70; C12N15/82; C12P33/20
Domestic Patent References:
| WO2009146362A1 | 2009-12-03 |
Foreign References:
| CN104232723A | 2014-12-24 |
Other References:
DATABASE GENBANK 27 April 2014 (2014-04-27), Database accession no. KJ403006.1
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
上海一平知识产权代理有限公司 (CN)
上海一平知识产权代理有限公司 (CN)
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