Title:
MUTANT TRANSGLUTAMINASE
Document Type and Number:
WIPO Patent Application WO/2022/071061
Kind Code:
A1
Abstract:
Provided is a mutant transglutaminase (mutant TG) having high heat tolerance and/or high pH stability. This mutant TG has a mutation at an amino acid residue such as D1, Y24, R48, S101, G102, N139, D142, L147, K152, G157, R167, N176, K181, E182, H188, D189, R208, T245, S246, G250, G275, S284, H289, G301 or K327 and/or a mutation that introduces a disulfide bond.
Inventors:
TAKAHASHI KAZUTOSHI (JP)
ONO TAKUTO (JP)
ARAKI NAO (JP)
KOBAYASHI HIROAKI (JP)
ONO TAKUTO (JP)
ARAKI NAO (JP)
KOBAYASHI HIROAKI (JP)
Application Number:
PCT/JP2021/034780
Publication Date:
April 07, 2022
Filing Date:
September 22, 2021
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
A23C9/12; A21D2/26; A21D13/00; A23C19/08; A23D7/00; A23D9/00; A23D9/007; A23G9/36; A23L2/00; A23L2/02; A23L5/00; A23L7/10; A23L7/109; A23L11/00; A23L11/45; A23L13/00; A23L13/40; A23L13/60; A23L15/00; A23L17/00; A23L17/60; A23L19/00; A23L19/10; A23L25/00; A23L27/00; A23L27/20; A23L29/281; C12N1/19; C12N1/21; C12N9/10; C12N15/31; C12N15/54
Domestic Patent References:
| WO2010101256A1 | 2010-09-10 | |||
| WO2008099898A1 | 2008-08-21 | |||
| WO2019107288A1 | 2019-06-06 | |||
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| WO2019107288A1 | 2019-06-06 | |||
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DATSENKO, K.A.WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
MANDEL, M.HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159 - 162
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HINNEN, AHICKS, J.B.FINK, G.R., PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929 - 1933
ENVIRON. MICROBIOL., vol. 69, no. 1, 2003, pages 358 - 366
TAKAGI,J. ET AL., ANAL. BIOCHEM., vol. 153, 1986, pages 296 - 298
APPL. ENVIRON. MICROBIOL., vol. 69, no. 1, 2003, pages 358 - 366
ELIZABETH C. TYLER ET AL., COMPUTERS AND BIOMEDICAL RESEARCH, vol. 24, no. 1, 1991, pages 72 - 96
BARTON GJ ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 198, no. 2, 1987, pages 327 - 37
BACKMANN B.J.: "Escherichia coli and Salmonella Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, article "Derivations and Genotypes of some mutant derivatives of Escherichia coli K-12", pages: 2460 - 2488
ADELOU M. ET AL.: "Genome-based phylogeny and taxonomy of the 'Enterobacteriales': proposal for Enterobacterales ord. nov. divided into the families Enterobacteriaceae, Erwiniaceae fam. nov., Pectobacteriaceae fam. nov., Yersiniaceae fam. nov., Hafniaceae fam. nov., Morganellaceae fam. nov., and Budviciaceae fam. nov.", INT. J. SYST. EVOL. MICROBIOL., vol. 66, 2016, pages 5575 - 5599
INT. J. SYST. BACTERIOL., vol. 41, 1991, pages 255
INT. J. SYST. EVOL. MICROBIOL., vol. 60, 2010, pages 874 - 879
PLASMID, vol. 12, 1984, pages 1 - 9
HIGUCHI, R.: "PCR Technology", vol. 61, 1989, STOCKTON PRESS
CARTER P., METH., IN ENZYMOL, vol. 154, 1987, pages 382
KRAMER, W.FRITS, H.J., METH. IN ENZYMOL, vol. 154, 1987, pages 350
KUNKEL, T.A. ET AL., METH. IN ENZYMOL., vol. 154, 1987, pages 367
APPL. MICROBIOL. BIOTECHNOL., vol. 53, 2000, pages 674 - 679
JOURNAL OF BIOTECHNOLOGY, vol. 104, 2003, pages 311 - 323
APPL. ENVIRON. MICROBIOL., vol. 71, no. 12, December 2005 (2005-12-01), pages 8587 - 96
GOLDSTEIN ET AL.: "Prokaryotic Promoters in Biotechnology", BIOTECHNOL. ANNU. REV., vol. 1, 1995, pages 105 - 128, XP008038474
AGRIC. BIOL. CHEM., vol. 48, 1984, pages 2901 - 2903
"Genetic Engineering", vol. 8, 1987, KYORITSU SHUPPAN CO., LTD, article "Fundamental Microbiology"
MILLER, J.H.: "Experiments in Molecular Genetics", 1972, COLD SPRING HARBOR LABORATORY
DATSENKO, K.A.WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
MANDEL, M.HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159 - 162
DUNCAN, C.H.WILSON, G.AYOUNG, F.E, GENE, vol. 1, 1977, pages 153 - 167
CHANG, S.CHOEN, S.N., MOL. GEN. GENET., vol. 168, 1979, pages 111 - 115
BIBB, M.J.WARD, J.M.HOPWOOD, O.A., NATURE, vol. 274, 1978, pages 398 - 400
HINNEN, AHICKS, J.B.FINK, G.R., PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929 - 1933
ENVIRON. MICROBIOL., vol. 69, no. 1, 2003, pages 358 - 366
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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