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Patent Searching and Data


Title:
MUTATED AMYLOID PROTEIN
Document Type and Number:
WIPO Patent Application WO/2006/038729
Kind Code:
A1
Abstract:
It is intended to provide a novel amyloid protein (a human mutated amyloid protein) which is useful as, for example, an antigen molecule for improving a vaccine therapy. This human mutated amyloid protein is a protein which lacks Glu at the 22-position, Ala at the 21-position or Asp at the 23-position in a normal (wild type) amyloid protein consisting of 40, 42 or 43 amino acids (Aβ1-40, Aβ1-42 or Aβ1-43) respectively.

Inventors:
MORI HIROSHI (JP)
TOMIYAMA TAKAMI (JP)
SHIMADA HIROYUKI (JP)
Application Number:
PCT/JP2005/018896
Publication Date:
April 13, 2006
Filing Date:
October 06, 2005
Export Citation:
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Assignee:
MORI HIROSHI (JP)
TOMIYAMA TAKAMI (JP)
SHIMADA HIROYUKI (JP)
International Classes:
C12N15/09; A01K67/027; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P25/28; A61P43/00; C07K7/06; C07K7/08; C07K14/47; C07K16/18; C12N5/07; C12N5/071; C12N5/10; C12Q1/02; G01N33/15; G01N33/50; G01N33/68
Foreign References:
JP2003534351A2003-11-18
US20030166558A12003-09-04
US20040091945A12004-05-13
Other References:
"Alzheimer-disease-like pathology in the PDAPP mouse", NATURE, vol. 400, 1999, pages 173 - 6
NICOLL, J.A.R. ET AL.: "Neuropathology of human Alzheimer disease after immunization with amyloid- peptide: a case report", NATURE MED., vol. 9, 2003, pages 448 - 452
DEMATTOS ET AL., SCIENCE, vol. 295, 2002, pages 2264 - 7
PFEIFER, M. ET AL.: "Cerebral hemorrhage after passive anti-Aj3 immunotherapy", SCIENCE, vol. 298, 2002, pages 1379
See also references of EP 1811025A4
Attorney, Agent or Firm:
Nishizawa, Toshio (11-1 Minami-Aoyama 6-chom, Minato-ku Tokyo, JP)
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