Title:
MUTATED 6−PHOSPHOGLUCONATE DEHYDROGENASE
Document Type and Number:
WIPO Patent Application WO/2003/048351
Kind Code:
A1
Abstract:
A polypeptide having an amino acid sequence of 6−phosphogluconate dehydrogenase (hereinafter abbreviated as GND) originating in a microorganism belonging to the genus Corynebacterium, which is derived from the amino acid sequence represented by SEQ ID NO:1 by the substitution of the amino acid residue(s) corresponding to the amino acid(s) at the 158th position and&sol or the 361st position, and having a GND activity&semi a DNA encoding this polypeptide&semi a recombinant DNA having this DNA&semi a transformant having this recombinant DNA&semi a microorganism having the above DNA on its chromosome&semi and a process for producing a useful substance characterized by culturing the above transformant or the above microorganism in a medium.
Inventors:
IKEDA MASATO (JP)
OHNISHI JUNKO (JP)
MITSUHASHI SATOSHI (JP)
OCHIAI KEIKO (JP)
OHNISHI JUNKO (JP)
MITSUHASHI SATOSHI (JP)
OCHIAI KEIKO (JP)
Application Number:
PCT/JP2002/012661
Publication Date:
June 12, 2003
Filing Date:
December 03, 2002
Export Citation:
Assignee:
KYOWA HAKKO KOGYO KK (JP)
IKEDA MASATO (JP)
OHNISHI JUNKO (JP)
MITSUHASHI SATOSHI (JP)
OCHIAI KEIKO (JP)
IKEDA MASATO (JP)
OHNISHI JUNKO (JP)
MITSUHASHI SATOSHI (JP)
OCHIAI KEIKO (JP)
International Classes:
C12N1/21; C12N9/04; C12N15/53; C12P13/04; C12P13/06; C12P13/08; C12P13/10; C12P13/22; (IPC1-7): C12N9/04; C12N15/53; C12N1/21; C12P13/04; C12P19/00
Domestic Patent References:
| WO1995011985A1 | 1995-05-04 | |||
| WO2001004325A1 | 2001-01-18 | |||
| WO2000034484A1 | 2000-06-15 |
Foreign References:
| JPH09224662A | 1997-09-02 | |||
| EP1108790A2 | 2001-06-20 | |||
| EP1108790A2 | 2001-06-20 |
Other References:
J. MOL. BIOL., vol. 215, 1990, pages 403
METHODS IN ENZYMOLOGY, vol. 183, 1990, pages 63 - 98
STRATEGIES, vol. 5, 1992, pages 81
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1983, pages 1
J. MOL. BIOL., vol. 16, 1966, pages 118
GENE, vol. 38, 1985, pages 275
METHODS IN ENZYMOLOGY, vol. 183, 1990, pages 63 - 98
STRATEGIES, vol. 5, 1992, pages 81
GENETICS, vol. 39, 1954, pages 440
SCIENCE, vol. 222, 1983, pages 778
J. MOL. BIOL., vol. 166, 1983, pages 1
J. MOL. BIOL., vol. 16, 1966, pages 118
GENE, vol. 38, 1985, pages 275
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