MUTILIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Title:

MUTILIN DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

Document Type and Number:

WIPO Patent Application WO2007037518

Kind Code:

A9

Abstract:

The invention is intended to provide a novel compound which is useful as an antibacterial agent and a manufacturing intermediate thereof and relates to a mutilin derivative represented by the formula (I) which is useful as an antibacterial agent against a multidrug resistant organism, a manufacturing intermediate thereof and the like. In the formula (I), R¹ represents an ethyl group or a vinyl group, P¹ represent H or a protecting group for a hydroxy group, R² and R³ represent H or the like, G represents CH₂ or the like, A represents -S-, -SO₂-, -O- or the like, m represents an integer of 0 to 4, the Q¹ ring represents a saturated heterocyclic group, R⁴ represents H, a lower alkyl group or the like, and W represents a group represented by the formula (W-1) or an amino protection group. In the formula (W-1), X represents a lower alkylene chain, a single bond or the like, Z¹ represents CH or the like, Z², Z³ and Z⁴ represent N or the like, and Y¹ and Y² represent H, an amino group, a group represented by the formula (Y-1) or the like. In the formula (Y-1), the Q² ring represents a saturated heterocyclic group, and R⁹ and R¹⁰ represents H, a lower alkyl group or the like. (I) (W-1) (Y-1)

Inventors:

HIROKAWA YOSHIMI (JP)
KATO SHIRO (JP)
KOJIMA TSUYOSHI (JP)

Application Number:

PCT/JP2006/319919

Publication Date:

May 31, 2007

Filing Date:

September 28, 2006

Export Citation:

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Assignee:

DAINIPPON SUMITOMO PHARMA CO (JP)
HIROKAWA YOSHIMI (JP)
KATO SHIRO (JP)
KOJIMA TSUYOSHI (JP)

International Classes:

C07D205/04; A61K9/08; A61K31/397; A61K31/40; A61K31/437; A61K31/439; A61K31/445; A61K31/4468; A61K31/519; A61K31/52; A61K31/5375; A61K31/5377; A61K31/55; A61K31/553; A61P31/04; C07D207/09; C07D207/14; C07D211/34; C07D211/42; C07D211/46; C07D211/54; C07D211/58; C07D223/04; C07D265/30; C07D267/10; C07D451/02; C07D471/04; C07D473/16; C07D473/34; C07D487/04; C07D519/00

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