Title:
MYCOBACTERIOPHAGE CAPABLE OF DELIVERING AUTONOMOUS LUMINESCENT ELEMENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/152482
Kind Code:
A1
Abstract:
Provided are a mycobacteriophage capable of delivering an autonomous luminescent element and a use thereof. The mycobacteriophage contains a gene LuxCDABE needed for the autonomous luminescence in a host bacterium. The autonomous luminescent element is present on a transposon and can be randomly inserted into the genome of the host bacterium along with the transposable element. The mycobacteriophage can be used to rapidly diagnose live host bacteria in a sample and to rapidly detect the sensitivity of the host bacteria to a drug.
Inventors:
ZHANG TIANYU (CN)
LIU ZHIYONG (CN)
LIU ZHIYONG (CN)
Application Number:
PCT/CN2016/081202
Publication Date:
September 14, 2017
Filing Date:
May 06, 2016
Export Citation:
Assignee:
GUANGZHOU INST BIOMED & HEALTH (CN)
International Classes:
C12N15/70; C12N7/01; C12Q1/02; C12Q1/04; C12Q1/70; C12R1/32; C12R1/92
Domestic Patent References:
| WO2010097411A1 | 2010-09-02 |
Foreign References:
| CN1884555A | 2006-12-27 |
Other References:
JACOBS, W.R. ET AL.: "Rapid Assessment of Drug Susceptibilities of Mycobacterium Tuberculosis by Means of Luciferase Reporter Phages", SCIENCE, vol. 260, no. 5109, 7 May 1993 (1993-05-07), XP002917193, ISSN: 0036-8075
HUANG, HAIRONG ET AL.: "Application of Phages in Mycobacterium Tuberculosis Research", CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES, vol. 25, no. 8, 12 August 2002 (2002-08-12), ISSN: 1001-0939
HUANG, HAIRONG ET AL.: "Application of Phages in Mycobacterium Tuberculosis Research", CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES, vol. 25, no. 8, 12 August 2002 (2002-08-12), ISSN: 1001-0939
Attorney, Agent or Firm:
JIAQUAN IP LAW FIRM (CN)
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