Title:
MYOGENESIS INDUCING AGENT
Document Type and Number:
WIPO Patent Application WO/2018/070510
Kind Code:
A1
Abstract:
Provided is an agent developed to be capable of alleviating and suppressing muscle atrophy or muscle mass reduction, even for the elderly and even without requiring exercise, by inducing myogenesis. Provided is a composition for treating or preventing disorders or diseases associated with muscle atrophy, or for promoting muscle regeneration, the composition containing, as an active ingredient, a myogenesis inducing agent composed of miR-199 or an DNA that contains an miR-199 gene encoding the miR-199.
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Inventors:
HOHJOH HIROHIKO (JP)
FUKUOKA MASASHI (JP)
FUKUOKA MASASHI (JP)
Application Number:
PCT/JP2017/037120
Publication Date:
April 19, 2018
Filing Date:
October 13, 2017
Export Citation:
Assignee:
NAT CENTER NEUROLOGY & PSYCHIATRY (JP)
International Classes:
A61K31/7105; A61P21/00; C12N15/113
Foreign References:
| JP2009519339A | 2009-05-14 |
Other References:
ZHOU, B. ET AL.: "MicroRNA expression profiles of porcine skeletal muscle", ANIMAL GENETICS, vol. 41, 2010, pages 499 - 508, XP055476188
JIA, L. ET AL.: "MiRNA-199a-3p regulates C2C12 myoblast differentiation through IGF-1/AKT/mTOR signal pathway", INT. J. MOL. SCI., vol. 15, 2013, pages 296 - 308, XP055476192
CHEN, X. ET AL.: "MiRNAs regulates skeletal muscle development via down-regulation of myosin heavy chain", FASEB, J., vol. 27, no. 939, 2013, pages 12, XP009515264, DOI: 10.1096/fasebj.27.1_supplement.939.12
FUKUOKA, MASAYUKI ET AL.: "Analysis of miRNA in Blood of Young and Old Mice: Young Mouse High-expression miRNA Involving in Differentiation of Muscle", THE 38TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JOINT MEETING OF THE 88TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, vol. 8, no. 8, 2015, pages 1P1174, XP009516451
See also references of EP 3527212A4
JIA, L. ET AL.: "MiRNA-199a-3p regulates C2C12 myoblast differentiation through IGF-1/AKT/mTOR signal pathway", INT. J. MOL. SCI., vol. 15, 2013, pages 296 - 308, XP055476192
CHEN, X. ET AL.: "MiRNAs regulates skeletal muscle development via down-regulation of myosin heavy chain", FASEB, J., vol. 27, no. 939, 2013, pages 12, XP009515264, DOI: 10.1096/fasebj.27.1_supplement.939.12
FUKUOKA, MASAYUKI ET AL.: "Analysis of miRNA in Blood of Young and Old Mice: Young Mouse High-expression miRNA Involving in Differentiation of Muscle", THE 38TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JOINT MEETING OF THE 88TH ANNUAL MEETING OF THE MOLECULAR BIOLOGY SOCIETY OF JAPAN, vol. 8, no. 8, 2015, pages 1P1174, XP009516451
See also references of EP 3527212A4
Attorney, Agent or Firm:
HIRAKI & ASSOCIATES (JP)
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