Title:
MYOGENIC DIFFERENTIATION-PROMOTING ACTIVITIES OF ERGOTHIONEINE, ASCORBIC ACID 2-GLUCOSIDE, ASCORBIC ACID, AND COMBINATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/004014
Kind Code:
A1
Abstract:
The present invention provides: a culture medium and a culture medium additive which are for myogenic differentiation promotion and which contain ergothioneine, ascorbic acid 2-glucoside, ascorbic acid, or a combination thereof; a kit; and a pharmaceutical composition and food and drink for myogenic differentiation promotion.
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Inventors:
KOSAKA KUNIO (JP)
Application Number:
PCT/JP2019/023114
Publication Date:
January 02, 2020
Filing Date:
June 11, 2019
Export Citation:
Assignee:
NAGASE & CO LTD (JP)
International Classes:
A23L33/175; C12N5/077; A61K31/4172; A61P21/00; C12N1/00
Foreign References:
| US20150157648A1 | 2015-06-11 | |||
| JP2009167169A | 2009-07-30 |
Other References:
MITSUMOTO Y. ET AL.: "A LONG-LASTING VITAMIN C DERIVATIVE, ASCRBIC ACID 2-PHOSPHATE, INCREASES MYOGENIN GENE EXPRESSION AND PROMOTES DIFFERENTIATION IN L6 MUSCLE CELLS", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 199, no. 1, 28 February 1994 (1994-02-28), pages 394 - 402, XP024764982, ISSN: 0006-291X, DOI: 10.1006/bbrc.1994.1242
ÖZTÜRKLER Y. ET AL.: "The Effects of L-Ergothioneine and L-Ascorbic Acid on the In Vitro Maturation (IVM) and Embryonic Development (IVC) of Sheep Oocytes", KAFKAS UNIV VET FAK DERG, vol. 16, no. 5, 1 January 2010 (2010-01-01), pages 757 - 763, XP055666935, ISSN: 1300-6045, DOI: 10.9775/kvfd.2009.1646
ONITSUKA Y: "Investigation of an efficient culture condition for the differentiation of murine skeletal myoblasts", JPN. J. VET. RES., vol. 61, no. 1, 2, 2013, pages 39
See also references of EP 3816278A4
ÖZTÜRKLER Y. ET AL.: "The Effects of L-Ergothioneine and L-Ascorbic Acid on the In Vitro Maturation (IVM) and Embryonic Development (IVC) of Sheep Oocytes", KAFKAS UNIV VET FAK DERG, vol. 16, no. 5, 1 January 2010 (2010-01-01), pages 757 - 763, XP055666935, ISSN: 1300-6045, DOI: 10.9775/kvfd.2009.1646
ONITSUKA Y: "Investigation of an efficient culture condition for the differentiation of murine skeletal myoblasts", JPN. J. VET. RES., vol. 61, no. 1, 2, 2013, pages 39
See also references of EP 3816278A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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