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Title:
N-ACETYLGLUCOSAMINE DERIVATIVES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2004/033474
Kind Code:
A1
Abstract:
An acetylated N-acetylglucosamine derivative represented by the following general formula (1) and a hyaluronic acid production promoter containing the same and a skin preparation for external use containing the same. General formula (1): wherein R1 represents hydrogen or C2-18 alkyl; R2, R3 and R4 may be either the same or different and each represents hydrogen or C2-18 acyl; and the stereostructure at the 1-position may be either &agr - or β-structure, provided that R1, R2, R3 and R4 do not represent hydrogen at the same time. It is intended to provide an easily available hyaluronic acid production promoter and a skin preparation for external use by which the production of hyaluronic acid can be promoted in the skin and thus the skin can be maintained in a firm and moisten state so that it is expected that the human skin can be prevented from aging.

Inventors:
Fukunaga, Kyoko (3-2-9, Minamikamonomiya Odawara-shi, Kanagawa, 250-0875, JP)
Sayo, Tetsuya (220-1-405, Iizumi Odawara-shi, Kanagawa, 250-0863, JP)
Sakai, Shingo (1082-1, Kuno Odawara-shi, Kanagawa, 250-0055, JP)
Inoue, Shintaro (2235-5, Sobi Odawara-shi, Kanagawa, 250-0851, JP)
Application Number:
PCT/JP2003/009428
Publication Date:
April 22, 2004
Filing Date:
July 25, 2003
Export Citation:
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Assignee:
KANEBO, COSMETICS INC. (20-20, Kaigan 3-chome, Minato-k, Tokyo, 108-8080, JP)
Fukunaga, Kyoko (3-2-9, Minamikamonomiya Odawara-shi, Kanagawa, 250-0875, JP)
Sayo, Tetsuya (220-1-405, Iizumi Odawara-shi, Kanagawa, 250-0863, JP)
Sakai, Shingo (1082-1, Kuno Odawara-shi, Kanagawa, 250-0055, JP)
Inoue, Shintaro (2235-5, Sobi Odawara-shi, Kanagawa, 250-0851, JP)
International Classes:
A61K8/60; A61P17/16; A61P43/00; A61Q19/00; A61Q19/08; C07H13/06; C07H15/04; A61Q17/04; A61Q19/10; (IPC1-7): C07H15/04; A61K7/00; A61K7/48; A61K31/7024; A61K31/7028; A61P17/16; A61P43/00; C07H13/06
Foreign References:
US5696246A1997-12-09
JPS6236306A1987-02-17
JPH02243611A1990-09-27
JP2001002551A2001-01-09
EP1075836A22001-02-14
JPH08143588A1996-06-04
Other References:
SAKAI SHINGO ET AL.: 'Hyohi saibo hyaluronic-san sansei sokushin sayo o motsu ten'nengata N-acetylglucosamine' FINE CHEMICAL vol. 30, no. 22, 15 December 2001, pages 5 - 11, XP002977478
See also references of EP 1553101A1
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