Title:
N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS
Document Type and Number:
WIPO Patent Application WO2002024636
Kind Code:
A3
Abstract:
N-Benzoyl arylsulfonamides having the formula (I) are BCL-Xl inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-Xl inhibiting compositions and methods of promoting apoptosis in a mammal.
Inventors:
MCCLELLAN WILLIAM
OOST THORSTEN
BRUNCKO MILAN
WANG XILU
AUGERI DAVID J
BAUMEISTER STEVEN A
DICKMAN DANIEL A
DING HONG
DINGES JURGEN
FESIK STEPHEN W
HAJDUK PHILIP J
KUNZER AARON R
NETTESHEIM DAVID G
PETROS ANDREW M
ROSENBERG SAUL H
SHEN WANG
THOMAS SHEELA A
WENDT MICHAEL D
OOST THORSTEN
BRUNCKO MILAN
WANG XILU
AUGERI DAVID J
BAUMEISTER STEVEN A
DICKMAN DANIEL A
DING HONG
DINGES JURGEN
FESIK STEPHEN W
HAJDUK PHILIP J
KUNZER AARON R
NETTESHEIM DAVID G
PETROS ANDREW M
ROSENBERG SAUL H
SHEN WANG
THOMAS SHEELA A
WENDT MICHAEL D
Application Number:
PCT/US2001/029432
Publication Date:
September 26, 2002
Filing Date:
September 20, 2001
Export Citation:
Assignee:
ABBOTT LAB (US)
International Classes:
A61K31/18; A61K31/428; A61K31/63; A61K31/635; A61P9/10; A61P25/16; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P37/02; C07C311/46; C07C311/51; C07C317/28; C07C323/12; C07C323/17; C07C323/25; C07C323/30; C07C323/37; C07C323/43; C07C323/44; C07C323/48; C07C323/58; C07C323/60; C07D203/10; C07D205/04; C07D205/12; C07D207/09; C07D207/24; C07D207/404; C07D209/08; C07D209/52; C07D209/54; C07D209/96; C07D211/14; C07D211/44; C07D211/70; C07D211/74; C07D213/56; C07D213/61; C07D213/64; C07D213/69; C07D213/70; C07D213/71; C07D215/14; C07D215/227; C07D215/38; C07D215/48; C07D217/04; C07D221/20; C07D231/12; C07D233/60; C07D235/08; C07D235/26; C07D241/08; C07D241/16; C07D249/04; C07D263/32; C07D263/56; C07D263/58; C07D277/62; C07D277/64; C07D295/13; C07D295/155; C07D295/16; C07D295/185; C07D295/20; C07D295/205; C07D295/215; C07D295/26; C07D307/14; C07D317/54; C07D333/28; C07D333/68; C07D333/70; C07D401/06; C07D401/12; C07D405/04; C07D405/06; C07D417/12; C07D451/02; C07D491/107; C07D207/40; C07D215/22; (IPC1-7): C07C311/51; C07C317/28; C07C323/12; C07C323/17; C07C323/25; C07C323/30; C07C323/37; C07C323/58; C07C323/60; C07D209/08; C07D209/96; C07D213/61; C07D213/70; C07D215/48; C07D221/20; C07D263/56; C07D277/62; C07D277/64; C07D295/14; C07D295/20; C07D317/58; C07D333/28; A61K31/18; A61P35/00
Foreign References:
| EP0837056A2 | 1998-04-22 |
Other References:
J.C. PENA, ET AL.: "Bcl-XL and Bcl-2 expression in squamous cell carcinoma of the head and neck", CANCER, vol. 85, no. 1, 1 January 1999 (1999-01-01), American Cancer Society, Philadelphia, PA, US, pages 164 - 170, XP002201723, ISSN: 0008-543X
V.L. DUBINA, ET AL.: "Arenesulphonyl benzamide chlorides. I. Synthesis and investigation of hydrolysis and reaction with amines", JOURNAL OF ORGANIC CHEMISTRY OF THE USSR (ZHURNAL ORGANICHESKOI KHIMII), vol. 2, no. 9, September 1966 (1966-09-01), Consultants Bureau, New York, US, pages 1809 - 1812, XP008003544, ISSN: 0022-3271
M.M. KREMLEV, ET AL.: "Investigation in the field of arenesulphonamides. LXXXIX. Aresulphonamidation of aromatic aldehydes and formamides", JOURNAL OF ORGANIC CHEMISTRY OF THE USSR (ZHURNAL ORGANICHESKOI KHIMII), vol. 13, no. 1, pt. 1, January 1977 (1977-01-01), Consultants Bureau, New York, US, pages 134 - 138, XP008003543, ISSN: 0022-3271
CHEMICAL ABSTRACTS, vol. 77, no. 9, 28 August 1972, Columbus, Ohio, US; abstract no. 61444j, M.M. KREMLEV, ET AL.: "Arenesulphonylamides. LXII. Arenesulphonyl-p-halobenzamides" page 457; XP002200109
J.P. ENGLISH, ET AL.: "Studies in chemotherapy. XIV. Antimalarials. The synthesis of substituted metanilamides and related compounds", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 68, no. 6, 18 June 1946 (1946-06-18), American Chemical Society, Washington, DC, US, pages 1039 - 1049, XP002200108, ISSN: 0002-7863
CHEMICAL ABSTRACTS, vol. 82, no. 21, 26 May 1975, Columbus, Ohio, US; abstract no. 139564y, M.T. PLOTNIKOVA, ET AL.: "Arenesulphonamides. LXXX. Aroylarenesulphonamides" page 579; XP002201725
A.K. SRIVASTAVA, ET AL.: "Synthesis of diaryl sulphonates and N-acyl-aryl sulphonamides as potential fungicides", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 40, no. 4, 1976, Japan Society for Bioscience, Biotechnology and Agrochemistry, Tokyo, JP, pages 805 - 806, XP002201724, ISSN: 0002-1369
PATENT ABSTRACTS OF JAPAN vol. 009, no. 317 (C - 319) 12 December 1985 (1985-12-12)
O.M.O. HABIB, ET AL.: "Synthesis of some new N-aroylsulphonamides and sulphonate esters of xylene sulphonic acids of potential biological activity", HUNGARIAN JOURNAL OF INDUSTRIAL CHEMISTRY, vol. 14, no. 4, 1986, LAPK, Budapest, HU, pages 477 - 483, XP008003823, ISSN: 0133-0276
V.L. DUBINA, ET AL.: "Arenesulphonyl benzamide chlorides. I. Synthesis and investigation of hydrolysis and reaction with amines", JOURNAL OF ORGANIC CHEMISTRY OF THE USSR (ZHURNAL ORGANICHESKOI KHIMII), vol. 2, no. 9, September 1966 (1966-09-01), Consultants Bureau, New York, US, pages 1809 - 1812, XP008003544, ISSN: 0022-3271
M.M. KREMLEV, ET AL.: "Investigation in the field of arenesulphonamides. LXXXIX. Aresulphonamidation of aromatic aldehydes and formamides", JOURNAL OF ORGANIC CHEMISTRY OF THE USSR (ZHURNAL ORGANICHESKOI KHIMII), vol. 13, no. 1, pt. 1, January 1977 (1977-01-01), Consultants Bureau, New York, US, pages 134 - 138, XP008003543, ISSN: 0022-3271
CHEMICAL ABSTRACTS, vol. 77, no. 9, 28 August 1972, Columbus, Ohio, US; abstract no. 61444j, M.M. KREMLEV, ET AL.: "Arenesulphonylamides. LXII. Arenesulphonyl-p-halobenzamides" page 457; XP002200109
J.P. ENGLISH, ET AL.: "Studies in chemotherapy. XIV. Antimalarials. The synthesis of substituted metanilamides and related compounds", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 68, no. 6, 18 June 1946 (1946-06-18), American Chemical Society, Washington, DC, US, pages 1039 - 1049, XP002200108, ISSN: 0002-7863
CHEMICAL ABSTRACTS, vol. 82, no. 21, 26 May 1975, Columbus, Ohio, US; abstract no. 139564y, M.T. PLOTNIKOVA, ET AL.: "Arenesulphonamides. LXXX. Aroylarenesulphonamides" page 579; XP002201725
A.K. SRIVASTAVA, ET AL.: "Synthesis of diaryl sulphonates and N-acyl-aryl sulphonamides as potential fungicides", AGRICULTURAL AND BIOLOGICAL CHEMISTRY, vol. 40, no. 4, 1976, Japan Society for Bioscience, Biotechnology and Agrochemistry, Tokyo, JP, pages 805 - 806, XP002201724, ISSN: 0002-1369
PATENT ABSTRACTS OF JAPAN vol. 009, no. 317 (C - 319) 12 December 1985 (1985-12-12)
O.M.O. HABIB, ET AL.: "Synthesis of some new N-aroylsulphonamides and sulphonate esters of xylene sulphonic acids of potential biological activity", HUNGARIAN JOURNAL OF INDUSTRIAL CHEMISTRY, vol. 14, no. 4, 1986, LAPK, Budapest, HU, pages 477 - 483, XP008003823, ISSN: 0133-0276
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