Title:
N-ALKANOYLPHENYLALANINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO1999010312
Kind Code:
B1
Abstract:
Compounds of formula (1) as well as their salts and esters are disclosed wherein X, X', Z and Y are as described in the specification and which have activity as inhibitors of binding between VCAM-1 and cells expressing VLA-4. Such compounds are useful for treating diseases whose symptoms and/or damage are related to the binding of VCAM-1 to cells expressing VLA-4.
Inventors:
CHEN LI
GUTHRIE ROBERT WILLIAM
HUANG TAI-NANG
HULL KENNETH G
SIDDURI ACHYTHARAO
TILLEY JEFFERSON WRIGHT
GUTHRIE ROBERT WILLIAM
HUANG TAI-NANG
HULL KENNETH G
SIDDURI ACHYTHARAO
TILLEY JEFFERSON WRIGHT
Application Number:
PCT/EP1998/005135
Publication Date:
June 03, 1999
Filing Date:
August 13, 1998
Export Citation:
Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
A61K31/165; A61K31/198; A61K31/216; A61K31/27; A61K31/277; A61K31/33; A61K31/41; A61K31/4192; A61K31/42; A61K31/426; A61K31/437; A61K31/44; A61K31/4418; A61K31/47; A61K31/496; A61K31/505; A61K31/519; A61K31/66; A61P1/00; A61P11/06; A61P19/02; A61P25/00; A61P29/00; C07C233/87; C07C235/52; C07C235/84; C07C237/22; C07C237/36; C07C275/42; C07C311/17; C07C311/21; C07C317/44; C07C317/50; C07C323/39; C07C323/62; C07D211/64; C07D213/82; C07D215/30; C07D215/50; C07D233/32; C07D233/36; C07D233/74; C07D233/80; C07D239/28; C07D249/06; C07D257/06; C07D261/18; C07D277/20; C07D277/56; C07D295/08; C07D295/14; C07D295/15; C07D401/12; C07D413/12; C07D471/04; C07D487/04; (IPC1-7): C07C233/87; C07C235/52; C07C237/36; C07C317/50; C07C323/39; C07D215/50; C07D233/32; C07D295/088; C07D487/04; A61K31/165; A61K31/33
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