Title:
N-ALKYL-HYDROXAMIC ACID-ISOINDOLYL COMPOUNDS AND THEIR PHARMACEUTICAL USES
Document Type and Number:
WIPO Patent Application WO2004080422
Kind Code:
A3
Abstract:
The invention encompasses novel N-alkyl-hydroxamic acid-isoindolyl compounds of formula (I) with the definition X1-X4, Z1, Z2, R1, R2, R7 and Y according to claim 1, pharmaceutical compositions of these compounds, and methods of using these compounds and compositions for treatment or prevention of various diseases and disorders mediated by PDE4 inhibition, associated with abnormal TNA-alpha levels, and/or mediated by MMP inhibition.
Inventors:
MAN HON-WAH (US)
MULLER GEORGE W (US)
MULLER GEORGE W (US)
Application Number:
PCT/US2004/007742
Publication Date:
October 28, 2004
Filing Date:
March 12, 2004
Export Citation:
Assignee:
CELGENE CORP (US)
MAN HON-WAH (US)
MULLER GEORGE W (US)
MAN HON-WAH (US)
MULLER GEORGE W (US)
International Classes:
A61K31/4035; A61K31/4178; A61K31/4196; A61K31/4245; A61K31/454; A61K31/496; A61K31/5377; C07D209/46; C07D209/48; C07D413/02; C07D417/02; (IPC1-7): C07D209/46
Domestic Patent References:
| WO2001045702A1 | 2001-06-28 | |||
| WO2002081447A1 | 2002-10-17 | |||
| WO1999006041A1 | 1999-02-11 | |||
| WO1995001348A2 | 1995-01-12 | |||
| WO2001034606A1 | 2001-05-17 |
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