N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE

Title:

N-ARYL AND N-HETEROARYL PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR β AGONISTS, COMPOSITIONS, AND THEIR USE

Document Type and Number:

WIPO Patent Application WO/2018/068297

Kind Code:

A1

Abstract:

Provided herein are certain substituted N-aryl and N-heteroaryl piperidine compounds of the formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, L, R4, L1, Q, R5 and R 6 are as defined. The said novel compounds, and pharmaceutically acceptable compositions comprising a compound thereof, may be useful as Liver X-β receptor(LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory disease and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.

Inventors:

RUDD MICHAEL T (US)
MENG ZHAOYANG (US)
WAI JENNY (US)
BENNETT DAVID JONATHAN (US)
BRNARDIC EDWARD J (US)
LIVERTON NIGEL J (US)
STACHEL SHAWN J (US)
HAN YONGXIN (US)
TEMPEST PAUL (CN)
ZHU JIUXIANG (CN)
XU XUEWANG (CN)

Application Number:

PCT/CN2016/102098

Publication Date:

April 19, 2018

Filing Date:

October 14, 2016

Export Citation:

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Assignee:

MERCK SHARP & DOHME (US)
RUDD MICHAEL T (US)
MENG ZHAOYANG (US)
WAI JENNY (US)
BENNETT DAVID JONATHAN (US)
BRNARDIC EDWARD J (US)
LIVERTON NIGEL J (US)
STACHEL SHAWN J (US)
HAN YONGXIN (US)
TEMPEST PAUL (CN)
ZHU JIUXIANG (CN)
XU XUEWANG (CN)

International Classes:

C07D401/04; A61K31/4409; A61P25/28; C07D211/26; C07D405/14

Domestic Patent References:

WO2016022521A1	2016-02-11
WO2011051282A1	2011-05-05

Attorney, Agent or Firm:

WU, FENG & ZHANG CO. (CN)

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