Title:
N-N-BIS-OXAZOLIDINONE ALKALOID COMPOUNDS, PREPARATION METHOD, AND USE IN MEDICAL FIELD
Document Type and Number:
WIPO Patent Application WO/2024/031997
Kind Code:
A1
Abstract:
The present invention relates to N-N-bis-oxazolidinone alkaloid compounds, a preparation method and a use in the medical field. The present invention provides two new N-N-bis-oxazolidinone alkaloid isomers isolated and purified from Lonicera japonica leaves and a preparation method therefor. The compound structure is as shown in Formula 1 or Formula 2 below. It has been verified that compounds 1 and 2 have significant protective effects against oxidative damage of liver cancer cells caused by AAPH. Moreover, both compounds 1 and 2 can inhibit, to varying degrees, the damage inflicted by APAP on HepG2 cells, and are expected to be used in the development of pharmaceutical pathways.
Inventors:
WANG XIAO (CN)
YU JINQIAN (CN)
LIU WEI (CN)
ZHAO HENGQIANG (CN)
YAN HUIJIAO (CN)
YU JINQIAN (CN)
LIU WEI (CN)
ZHAO HENGQIANG (CN)
YAN HUIJIAO (CN)
Application Number:
PCT/CN2023/083469
Publication Date:
February 15, 2024
Filing Date:
March 23, 2023
Export Citation:
Assignee:
SHANDONG ANALYSIS & TEST CT (CN)
International Classes:
A23L33/105; C07D263/26; A61K8/49; A61K31/422; A61P1/16; A61P3/10; A61P9/00; A61P13/12; A61P17/16; A61P35/00; A61P37/00; A61P39/00; A61P39/06; A61Q19/00
Foreign References:
| CN115160251A | 2022-10-11 | |||
| CN102391116A | 2012-03-28 | |||
| CN103720742A | 2014-04-16 | |||
| US20060014240A1 | 2006-01-19 | |||
| US20140193530A1 | 2014-07-10 |
Other References:
QIU SHUANG; BAI MING; ZHAO PENG; LIU ZHI-XIANG; HUANG XIAO-XIAO; SONG SHAO-JIANG: "Phytochemical and network-based chemotaxonomic study of Lonicera japonica Thunb", BIOCHEMICAL SYSTEMATICS AND ECOLOGY., PERGAMON PRESS., GB, vol. 94, 11 December 2020 (2020-12-11), GB , XP086468867, ISSN: 0305-1978, DOI: 10.1016/j.bse.2020.104210
WANG KAI, SHUANG LIU, MENG L I, LI ,, JIN-QIAN Y U, WANG XIAO: "Chemical constituents from Lonicera japonica leaves and their hepatoprotective activities", CHINESE TRADITIONAL AND HERBAL DRUGS, vol. 53, no. 8, 22 April 2022 (2022-04-22), pages 2285 - 2291, XP093137112, DOI: 10.7501/j.issn.0253-2670.2022.08.004
WANG KAI, SHUANG LIU, MENG L I, LI ,, JIN-QIAN Y U, WANG XIAO: "Chemical constituents from Lonicera japonica leaves and their hepatoprotective activities", CHINESE TRADITIONAL AND HERBAL DRUGS, vol. 53, no. 8, 22 April 2022 (2022-04-22), pages 2285 - 2291, XP093137112, DOI: 10.7501/j.issn.0253-2670.2022.08.004
Attorney, Agent or Firm:
JINAN SHENGDA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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