INTERNATIONAL SEARCH REPORT tinter..-, ional Application No PCT/US00/06747 C. (Continuation) DOCUMENTS CONSIDERED TO BE RELEVANT Category Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No. X DATABASE CHEMABS [Online] 1-3, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, 14-23 OHIO,US; YOSHIDA, HIROSHI ET AL :"Preparation of N- (2-chloroisonicotinoyl) amino acid amides as agrochemical microbicides" retrieved from STN Database accession no. 110: 213341 XP002144654 abstract &JP 63 301868 A (NIPPON KAYAKU CO., LTD., JAPAN) 8 December 1988 (1988-12-08) X DATABASE CHEMABS [Online] 1-3, CHEMICAL ABSTRACTS SERVICE, COLUMBUS, 14-23 OHIO,US ; SUZUE, SEIGO ET AL :"Hepatic agents. I. Synthesis of aminoacyl (and hydroxyacyl)aminoacetonitriles" retrieved from STN Database accession no. 70 : 11969 XP002144655 abstract &CHEM. PHARM. BULL. (TOKYO) (1968), 16 (8), 1417-32, X WO 98 01133 A (AIBE KAZUHIKO; NOSHIRO 1-3, OSAMU (JP); IGARASHI SUSUMU (JP); ISHII 14-23 YAS) 15 January 1998 (1998-01-15) page 79 P, X WO 99 24460 A (NOVARTIS ERFINDUNGEN 1-35 VERWALTUN ; ALTMANN EVA (CH); LATTMANN RENE (C) 20 May 1999 (1999-05-20) examples 1-419 2 international application No. INTERNATIONAL SEARCH REPORT PCT/US 00/06747 Box I Observations where certain claims were found unsearchable (Continuation of item 1 of first sheet) This International Search Report has not been established in respect of certain claims under Article 17 (2) (a) for the following reasons: 1. X Claims Nos.: because they relate to subject matter not required to be searched by this Authority, namely: Although claims 9-12,33 is directed to a method of treatment of the human/animal body, the search has been carried out and based on the alleged effects of the compound/composition. 2. Claims Nos. : 1-12,14-35 (partially) because they relate to parts of the International Application that do not comply with the prescribed requirements to such an extent that no meaningful International Search can be carried out, specifically : see FURTHER INFORMATION sheet PCT/ISA/210 3. jj Claims Nos.: because they are dependent claims and are not drafted in accordance with the second and third sentences of Rule 6.4 (a). Box 11 Observations where unity of invention is lacking (Continuation of item 2 of first sheet) This International Searching Authority found multiple inventions in this international application, as follows: see additional sheet 1. As all required additional search fees were timely paid by the applicant, this International Search Report covers all searchable claims. 2. jj As all searchable claims could be searched without effort justifying an additional fee, this Authority did not invite payment of any additional fee. 3. As only some of the required additional search fees were timely paid by the applicant, this International Search Report covers only those claims for which fees were paid, specifically claims Nos.: 4. No required additional search fees were timely paid by the applicant. Consequently, this International Search Report is restricted to the invention first mentioned in the claims; it is covered by claims Nos.: 1-12,14-35 (all partially) Remark on Protest The additional search fees were accompanied by the applicant's protest. u j No protest accompanied the payment of additional search fees. u FURTHER INFORMATION CONTINUED FROM PCT/ISA/210 This International Searching Authority found multiple (groups of) inventions in this international application, as follows: 1. Claims: 1-12,14-35 (all partially) Compounds of formula I, wherein X1=C (0), R4=H and R3=H or R4=H and R3= (Cl-6) Alkyl or R4=C (1-6) Alkyl. 2. Claims: 1-12,14-35 (all partially) Compounds of formula I, wherein X1=C (0), R4 is selected from subgroup (ii) and represents a functional group comprising a (poly) cyloalkyl or (poly) cycloaryl moiety. 3. Claims: 1-12,14-35 (all partially) A compound of formula I wherein X1=C (0) and R4 taken together with R2 or R3 forms a cyclic structure. 4. Claims: 1-12,14-35 (all partially) ; 13 A compound of formula I wherein X1=CH2S (0) 2. FURTHER INFORMATION CONTINUED FROM PCT/ISA/210 Continuation of Box 1. 2 Claims Nos.: 1-12,14-35 (partially) Present claims 1-35 relate to an extremely large number of possible compounds. In fact, the claims contain so many options, variables and possible permutations that a lack of clarity (and/or conciseness) within the meaning of Article 6 PCT arises to such an extent as to render a meaningful search of the claims impossible. The initial phase of the search revealed a very large number of documents relevant to the issue of novelty. So many documents were retrieved that it is impossible to determine which parts of the claim (s) may be said to define subject-matter for which protection might legitimately be sought (Article 6 PCT). For these reasons it appears impossible to execute a meaningful search and/or issue a complete search report over the whole breadth of the above mentioned claim (s). Consequently, the search and the report can only be considered complete for: First subject (see suppl. sheet B): Compounds as defined in the first invention, according to formula 1 comprising a moiety R9 as defined by claim 4. The applicant's attention is drawn to the fact that claims, or parts of claims, relating to inventions in respect of which no international search report has been established need not be the subject of an international preliminary examination (Rule 66.1 (e) PCT). The applicant is advised that the EPO policy when acting as an International Preliminary Examining Authority is normally not to carry out a preliminary examination on matter which has not been searched. This is the case irrespective of whether or not the claims are amended following receipt of the search report or during any Chapter II procedure. INTERNATIONAL SEARCH REPORT Inter,.-. ional Application No Informationonpatent familymembers PCT/US /06747 Patent document Publication Patent family Publication cited in search report date member (s) date JP 63301868 A 08-12-1988 NONE WO 9801133 A 15-01-1998 AU 3359697 A 02-02-1998 WO 9924460 A 20-05-1999 AU 1487399 A 31-05-1999 BR 9813197 A 29-08-2000 EP 1028942 A 23-08-2000 NO 20002320 A 04-07-2000 ZA 9810073 A 05-05-1999 JP 42009133 B NONE