Title:
N-CYCLOALKYL THIOOXAMIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2001/028991
Kind Code:
A1
Abstract:
N-Cycloalkyl thiooxamide derivatives represented by general formula (I) wherein R?1¿ represents alkyl, alkenyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkenylalkyl, alkoxyalkyl, dialkoxyalkyl, phenoxyalkyl, piperidinylalkyl, substituted phenyl, naphthyl, tetrahydronaphthyl, naphthylalkyl, pyridyl, phenylalkyl, phenylalkyl substituted at the benzene ring, etc. Drugs which have a novel function mechanism participating in the activation of T cells and mast cells participating in immunity and allergic reactions and inhibiting tyrosine phosphatase carried by CD45 antigen.
Inventors:
SATO MASAKAZU (JP)
KOBAYASHI YUKO (JP)
HAMAGUCHI TAKUYA (JP)
KOBAYASHI YUKO (JP)
HAMAGUCHI TAKUYA (JP)
Application Number:
PCT/JP2000/007245
Publication Date:
April 26, 2001
Filing Date:
October 19, 2000
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD (JP)
SATO MASAKAZU (JP)
KOBAYASHI YUKO (JP)
HAMAGUCHI TAKUYA (JP)
SATO MASAKAZU (JP)
KOBAYASHI YUKO (JP)
HAMAGUCHI TAKUYA (JP)
International Classes:
A61K31/16; A61K31/167; A61K31/36; A61K31/415; A61K31/426; A61K31/445; A61K31/4453; A61K31/495; A61K31/5375; A61P37/08; A61P43/00; C07C327/42; C07D277/46; C07D295/13; C07D295/205; (IPC1-7): C07C327/42; C07D295/13; C07D213/75; C07D307/52; C07D317/58; C07D231/40; C07D333/20; C07D211/58; C07D277/46; C07D295/16
Foreign References:
| DE1270552C2 | 1969-01-16 |
Other References:
YAROVENKO V.N. ET AL.: "Reactions of monothiooxamides with N-nucleophiles. Synthesis of 4,5-dihydroimidazole-2-carboxanilides", RUSS. CHEM. BULL., vol. 48, no. 4, 1999, pages 749 - 753, XP002936366
Attorney, Agent or Firm:
Kitagawa, Tomizo (Ltd Patent Division 24-1, Takata 3-chome Toshima-ku Tokyo, JP)
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