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Title:
N- SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS INHIBITION OF RORY ACTIVITY AND THE TREATMENT OF DISEASES
Document Type and Number:
WIPO Patent Application WO/2012/064744
Kind Code:
A3
Abstract:
The invention provides tetrahydroquinoline and related compounds, pharmaceutical compositions, methods of inhibiting RORϒ activity, reducing the amount of IL-17 in a subject, and treating immune disorders and inflammatory disorders using such tetrahydroquinoline and related compounds are provided.

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Inventors:
GLICK GARY D (US)
TOOGOOD PETER L (US)
ROMERO ARTHUR GLENN (US)
VANHUIS CHAD A (US)
AICHER THOMAS DANIEL (US)
KAUB CARL (US)
MATTSON MATTHEW N (US)
THOMAS WILLIAM DAVID (US)
STEIN KARIN ANN (US)
KROGH-JESPERSEN ERIK (US)
WANG ZHAN (US)
Application Number:
PCT/US2011/059788
Publication Date:
July 05, 2012
Filing Date:
November 08, 2011
Export Citation:
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Assignee:
LYCERA CORP (US)
GLICK GARY D (US)
TOOGOOD PETER L (US)
ROMERO ARTHUR GLENN (US)
VANHUIS CHAD A (US)
AICHER THOMAS DANIEL (US)
KAUB CARL (US)
MATTSON MATTHEW N (US)
THOMAS WILLIAM DAVID (US)
STEIN KARIN ANN (US)
KROGH-JESPERSEN ERIK (US)
WANG ZHAN (US)
International Classes:
C07D215/58; A61P37/00; C07D209/08; C07D209/34; C07D231/56; C07D241/50; C07D265/36; C07D401/04; C07D401/12; C07D403/12; C07D405/12; C07D409/12; C07D413/04; C07D413/12; C07D417/12
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Other References:
NICOLAS GUIMOND ET AL: "Rhodium(III)-Catalyzed Isoquinolone Synthesis: The N-O Bond as a Handle for C-N Bond Formation and Catalyst Turnover", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, no. 20, 26 May 2010 (2010-05-26), pages 6908 - 6909, XP055026521, ISSN: 0002-7863, DOI: 10.1021/ja102571b
MIN WANG ET AL: "Synthesis of new carbon-11-labeled 7-aroyl-aminoindoline-1-sulfonamides as potential PET agents for imaging of tubulin polymerization in cancers", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, vol. 51, no. 1, 1 January 2008 (2008-01-01), pages 6 - 11, XP055026537, ISSN: 0362-4803, DOI: 10.1002/jlcr.1462
YEH V S C ET AL: "Practical Cu-catalyzed amination of functionalized heteroaryl halides", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, NL, vol. 47, no. 34, 21 August 2006 (2006-08-21), pages 6011 - 6016, XP025004687, ISSN: 0040-4039, [retrieved on 20060821], DOI: 10.1016/J.TETLET.2006.06.119
BIAO JIANG ET AL: "synthesis and cytotoxicity evaluation of novel indolylpyrimidines and indolylpyrazines as potential antitumor agents", BIOORGANIC & MEDICINAL CHEMISTRY, PERGAMON, GB, vol. 9, 1 January 2001 (2001-01-01), pages 1149 - 1154, XP002665650, ISSN: 0968-0896
MASAYUKI MURASE ET AL: "A new concise synthesis of arcyriacyanin A and its unique inhibitory activity against a panel of human cancer cell line", CHEMICAL & PHARMACEUTICAL BULLETIN, 1 January 2000 (2000-01-01), pages 81 - 84, XP055026569
BOGER D L ET AL: "REGIOCONTROLLED NUCLEOPHILIC ADDITION TO SELECTIVELY ACTIVATED P-QUINONE DIIMINES: ALTERNATIVE PREPARATION OF A KEY INTERMEDIATE EMPLOYED IN THE PREPARATION OF THE CC-1065 LEFT-HAND SUBUNIT", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, EASTON.; US, vol. 55, no. 4, 1 January 1990 (1990-01-01), pages 1379 - 1390, XP002044433, ISSN: 0022-3263, DOI: 10.1021/JO00291A059
MINORU ISHIKURA ET AL: "An efficient synthesis of 3-heteroarylpyridines via diethyl-(3-pyridyl)-borane", SYNTHESIS, 1 January 1984 (1984-01-01), pages 936 - 938, XP055026581, Retrieved from the Internet [retrieved on 20120509]
Attorney, Agent or Firm:
DAVIS, Chad, E. et al. (Exchange PlaceBoston, MA, US)
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