Title:
N2-(2-METHOXYPHENYL)PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION FOR CANCER PREVENTION OR TREATMENT CONTAINING SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2016/167511
Kind Code:
A3
Abstract:
The present invention relates to an N2-(2-methoxyphenyl)pyrimidine derivative, a method for preparing the same, and a pharmaceutical composition for cancer prevention or treatment containing the same as an active ingredient. The N2-(2-methoxyphenyl)pyrimidine derivative according to the present invention, an optical isomer thereof, or a pharmaceutically acceptable salt thereof has excellent activity to inhibit anaplastic lymphoma kinase (ALK), thus has an excellent treatment effect on cancer cells having anaplastic lymphoma kinase (ALK) fusion proteins, such as EML4-ALK and NPM-ALK, and thus can be favorably used as a pharmaceutical composition for cancer prevention or treatment.
Inventors:
KIM PILHO (KR)
KIM HYOUNG RAE (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
JUNG HEE JUNG (KR)
YUN CHANG SOO (KR)
HWANG JONG YEON (KR)
PARK CHI HOON (KR)
LEE CHONG OCK (KR)
AHN SUNJOO (KR)
CHAE CHONG HAK (KR)
KIM HYOUNG RAE (KR)
CHO SUNG YUN (KR)
HA JAE DU (KR)
JUNG HEE JUNG (KR)
YUN CHANG SOO (KR)
HWANG JONG YEON (KR)
PARK CHI HOON (KR)
LEE CHONG OCK (KR)
AHN SUNJOO (KR)
CHAE CHONG HAK (KR)
Application Number:
PCT/KR2016/003597
Publication Date:
December 15, 2016
Filing Date:
April 06, 2016
Export Citation:
Assignee:
KOREA RES INST CHEMICAL TECH (KR)
International Classes:
C07D239/48; A61K31/505
Domestic Patent References:
| WO2015031666A1 | 2015-03-05 | |||
| WO2014203152A1 | 2014-12-24 | |||
| WO2014173291A1 | 2014-10-30 |
Foreign References:
| KR20090087127A | 2009-08-14 | |||
| KR20060039938A | 2006-05-09 |
Attorney, Agent or Firm:
LEE, Won Hee (Sung-ji Heights II147, Teheran-r, Gangnam-gu Seoul, KR)
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