Title:
N4 DERIVATIVES OF DEOXYCYTIDINE PRODRUGS
Document Type and Number:
WIPO Patent Application WO/2013/036846
Kind Code:
A3
Abstract:
The present invention provides hydrophobic prodrugs of nucleic acid bases, nucleosides, and nucleotides. The compounds of the invention have a structure according to Formula I. Methods for the hypomethylation of oligonucleotides, treatment of cancer, and treatment of HIV are also provided.
Inventors:
FROMHOLD MARK (US)
PARTRIDGE JOHN (US)
PARTRIDGE JOHN (US)
Application Number:
PCT/US2012/054277
Publication Date:
May 02, 2013
Filing Date:
September 07, 2012
Export Citation:
Assignee:
KORONIS PHARMACEUTICALS INC (US)
FROMHOLD MARK (US)
PARTRIDGE JOHN (US)
FROMHOLD MARK (US)
PARTRIDGE JOHN (US)
International Classes:
C07H19/12; A61K31/706; A61P31/18
Foreign References:
| US7772197B2 | 2010-08-10 | |||
| US20080249097A1 | 2008-10-09 | |||
| US20100075915A1 | 2010-03-25 | |||
| US4900828A | 1990-02-13 | |||
| US20080161548A1 | 2008-07-03 |
Attorney, Agent or Firm:
TRIMBLE, Alexander R. et al. (Two Embarcadero Center 8th Floo, San Francisco California, US)
Download PDF: