Title:
NKX3-1 saRNA AND KLF4 saRNA AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2011/112607
Kind Code:
A3
Abstract:
The present disclosure provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a NKX3-1 gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a promoter region sequence of the NKX3-1 gene. The present disclosure also provides compositions, pharmaceutical preparations, kits and methods for increasing expression of a KLF4 gene product in a cell by contacting the cell with a small activating RNA (saRNA) molecule comprising a ribonucleic strand that is complementary to a promoter region sequence of the KLF4 gene.
Inventors:
LI LONG-CHENG (US)
Application Number:
PCT/US2011/027587
Publication Date:
December 15, 2011
Filing Date:
March 08, 2011
Export Citation:
Assignee:
UNIV CALIFORNIA (US)
LI LONG-CHENG (US)
LI LONG-CHENG (US)
International Classes:
C07H21/02; A61P35/00
Domestic Patent References:
| WO2006113246A2 | 2006-10-26 |
Foreign References:
| US20070161031A1 | 2007-07-12 |
Other References:
HUANG ET AL.: "RNAa is conserved in mammalian cells. art. e8848", PLOS ONE., vol. 5, no. 1, 22 January 2010 (2010-01-22), pages 1 - 8
LIU ET AL.: "KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages.", BIOCHEM BIOPHYS RES COMM., vol. 362, no. 3., 26 October 2007 (2007-10-26), pages 575 - 581
WANG ET AL.: "Prognostic value and function of KLF4 in prostate cancer: RNAa and vector- mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration.", CLIN CANCER RES., vol. 70, no. 24, 15 December 2010 (2010-12-15), pages 10182 - 10191
CHECK E.: "RNA interference: hitting the on switch.", NATURE, vol. 448, no. 7156, 23 August 2007 (2007-08-23), pages 855 - 858
LIU ET AL.: "KLF4 regulates the expression of interleukin-10 in RAW264.7 macrophages.", BIOCHEM BIOPHYS RES COMM., vol. 362, no. 3., 26 October 2007 (2007-10-26), pages 575 - 581
WANG ET AL.: "Prognostic value and function of KLF4 in prostate cancer: RNAa and vector- mediated overexpression identify KLF4 as an inhibitor of tumor cell growth and migration.", CLIN CANCER RES., vol. 70, no. 24, 15 December 2010 (2010-12-15), pages 10182 - 10191
CHECK E.: "RNA interference: hitting the on switch.", NATURE, vol. 448, no. 7156, 23 August 2007 (2007-08-23), pages 855 - 858
Attorney, Agent or Firm:
BABA, Edward J. et al. (Suite 200East Palo Alto, California, US)
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