Title:
NOVEL ACETOACETYL-CoA REDUCTASE AND PROCESS FOR PRODUCING OPTICALLY ACTIVE ALCOHOL
Document Type and Number:
WIPO Patent Application WO/2005/044973
Kind Code:
A2
Abstract:
A process for easily producing optically active alcohols which are (R)-3-hydroxypentanenitrile, an optically active 3-hydroxybutanoic ester, and an optically active 1-phenylethanol derivative; and a novel enzyme useful for the production of the optically active alcohols, in particular, (R)-3-hydroxypentanenitrile. The enzyme is a novel acetoacetyl-CoA reductase which is capable of asymmetrically reducing 3-ketopentanenitrile to produce (R)-3-hydroxypentanenitrile having an optical purity of 99% e.e. or higher. The process comprises causing the novel enzyme or a known acetoacetyl-CoA reductase to act on each of 3-ketopentanenitrile, an acetoacetic ester, and a 1-phenylethanone derivative to produce the corresponding optically active alcohols.
Inventors:
KAWANO SHIGERU (JP)
YASOHARA YOSHIHIKO (JP)
YASOHARA YOSHIHIKO (JP)
Application Number:
PCT/JP2004/016666
Publication Date:
May 19, 2005
Filing Date:
November 10, 2004
Export Citation:
Assignee:
KANEKA CORP (JP)
KAWANO SHIGERU (JP)
YASOHARA YOSHIHIKO (JP)
KAWANO SHIGERU (JP)
YASOHARA YOSHIHIKO (JP)
International Classes:
C12N1/21; C12N9/02; C12N15/09; C12P7/04; C12P7/22; C12P7/42; C12P13/00; C12P41/00; C12N; (IPC1-7): C12N/
Domestic Patent References:
| WO2003031636A1 | 2003-04-17 |
Foreign References:
| JP2002541759A | 2002-12-10 |
Other References:
See references of EP 1688480A4
Attorney, Agent or Firm:
Yasutomi, Yasuo (4-20 Nishinakajima 5-chome, Yodogawa-k, Osaka-shi Osaka, JP)
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