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Title:
NOVEL AMIDE COMPOUND, AND Pin1 INHIBITOR, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES AND THERAPEUTIC AGENT FOR CANCER THAT USE THE SAME
Document Type and Number:
WIPO Patent Application WO/2019/031470
Kind Code:
A1
Abstract:
[Problem] The purpose of the invention is to develop, as drug-candidate compounds, a group of novel compounds having the activity of inhibiting functions of Pin1. [Solution] The invention provides: a compound represented by formula (I) or a salt thereof; and a Pin1 inhibitor, a pharmaceutical composition, a therapeutic or prophylactic agent for inflammatory diseases, a therapeutic or prophylactic agent for cancer, and a therapeutic or prophylactic agent for adiposity that use said compound/salt.

Inventors:
ASANO, Tomoichiro (HIROSHIMA UNIVERSITY 2-3, Kasumi 1-chome, Minami-ku, Hiroshima-sh, Hiroshima 53, 〒7348553, JP)
NAKATSU, Yusuke (HIROSHIMA UNIVERSITY 2-3, Kasumi 1-chome, Minami-ku, Hiroshima-sh, Hiroshima 53, 〒7348553, JP)
ITO, Hisanaka (1432-1 Horinouchi, Hachioji-sh, Tokyo 92, 〒1920392, JP)
OKABE, Takayoshi (3-1 Hongo 7-chome, Bunkyo-k, Tokyo 54, 〒1138654, JP)
Application Number:
JP2018/029495
Publication Date:
February 14, 2019
Filing Date:
August 06, 2018
Export Citation:
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Assignee:
HIROSHIMA UNIVERSITY (3-2 Kagamiyama 1-chome, Higashihiroshima-shi Hiroshima, 11, 〒7398511, JP)
TOKYO UNIVERSITY OF PHARMACY & LIFE SCIENCES (1432-1, Horinouchi Hachioji-sh, Tokyo 92, 〒1920392, JP)
THE UNIVERSITY OF TOKYO (3-1 Hongo 7-chome, Bunkyo-ku Tokyo, 54, 〒1138654, JP)
International Classes:
C07C233/87; A61K31/198; A61K31/216; A61K31/403; A61K31/55; A61P3/04; A61P29/00; A61P35/00; C07C233/51; C07C233/63; C07C235/40; C07C275/28; C07C275/36; C07C275/38; C07D209/82; C07D223/24; C07D265/38
Domestic Patent References:
WO2010012222A12010-02-04
Foreign References:
JPH07504184A1995-05-11
US20060079454A12006-04-13
JP2012530085A2012-11-29
JPH107540A1998-01-13
JPH01199994A1989-08-11
Other References:
DATABASE CAS [o] 14 December 2015 (2015-12-14), retrieved from STN Database accession no. 1829181-88-5
DATABASE CAS [o] 14 December 2015 (2015-12-14), retrieved from STN Database accession no. 1829120-71-9
DATABASE CAS [o] 14 April 2011 (2011-04-14), retrieved from STN Database accession no. 1279815-69-8
Attorney, Agent or Firm:
NAGASHIMA, Takaaki et al. (Hirakawa-cho KS Building 3rd Floor, 4-14 Hirakawa-cho 2-chome, Chiyoda-k, Tokyo 93, 〒1020093, JP)
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