Title:
NALFURAFINE-CONTAINING PREPARATION FOR TOPICAL APPLICATION
Document Type and Number:
WIPO Patent Application WO/2016/052617
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a nalfurafine-containing preparation for topical application that has high drug stability in the preparation and excellent drug transfer properties from the preparation to a living body.
The nalfurafine-containing preparation for topical application, which contains nalfurafine as a free compound and which contains an oily base comprising an emulsion base or a hydrocarbon-base oil and thus shows a residual ratio of nalfurafine of 90-100% after storing for 2 weeks at 60°C and a cumulative permeation amount of nalfurafine per unit area of 100 ng/cm2 or greater 20 hours after the application of the preparation in a rat skin permeation test, has high drug stability in the preparation and excellent drug transfer properties from the preparation to a living body.
Inventors:
NAGASE HIROSHI (JP)
SAIKI TAKESHI (JP)
SHIMOYAMA JUN (JP)
TADA MAKIKO (JP)
SAIKI TAKESHI (JP)
SHIMOYAMA JUN (JP)
TADA MAKIKO (JP)
Application Number:
PCT/JP2015/077741
Publication Date:
April 07, 2016
Filing Date:
September 30, 2015
Export Citation:
Assignee:
UNIV TSUKUBA (JP)
MIKASA SEIYAKU CO LTD (JP)
MIKASA SEIYAKU CO LTD (JP)
International Classes:
A61K31/485; A61K9/08; A61K9/10; A61K47/26; A61K47/44; A61P17/04; A61P25/00
Domestic Patent References:
| WO1998023290A1 | 1998-06-04 | |||
| WO2013099835A1 | 2013-07-04 | |||
| WO2009107478A1 | 2009-09-03 |
Foreign References:
| JP2013147459A | 2013-08-01 |
Other References:
MASAHIKO TAKANO: "Konnichi no Hifu Gaiyozai", KABUSHIKI KAISHA NANZANDO.4-1-11, 1981, Bunkyo-Ku, Tokyo, pages 235, ISBN: 4-525-77271-9
Attorney, Agent or Firm:
TAKASHIMA, HAJIME (JP)
Takashima 1 (JP)
Takashima 1 (JP)
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