Title:
NANO-COMPOSITION, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/041535
Kind Code:
A1
Abstract:
The present disclosure relates to a nano-composition, a preparation method therefor, and use thereof. The nano-composition is formed by self-assembly of an oligopeptide containing a tryptophan dipeptide motif and cisplatin. The general formula of the oligopeptide is Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-W-W-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12, wherein W is tryptophan, and Xaa1-Xaa12 are each independently absent or each independently represent an arbitrary amino acid residue. The nano-composition features mild preparation conditions, simple operation, environmental friendliness, etc., thus being suitable for industrial production and enabling efficient loading of medicaments. The nano-composition can be used for the preparation of anti-tumor medicaments.
Inventors:
SHI KAI (CN)
BI HONGSHU (CN)
BI HONGSHU (CN)
Application Number:
PCT/CN2023/114266
Publication Date:
February 29, 2024
Filing Date:
August 22, 2023
Export Citation:
Assignee:
GANZHOU HEMAY PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K47/69; A61K9/107; A61K33/24; A61K38/06; A61K45/00; A61K47/64; A61P35/00; B82Y5/00; B82Y40/00; C07K1/107; C07K5/093; C07K7/06
Foreign References:
| CN115554413A | 2023-01-03 | |||
| CN115368436A | 2022-11-22 | |||
| CN111135187A | 2020-05-12 | |||
| CN101732699A | 2010-06-16 | |||
| CN101870726A | 2010-10-27 | |||
| CN109513010A | 2019-03-26 | |||
| CN111748016A | 2020-10-09 | |||
| CN113383074A | 2021-09-10 |
Attorney, Agent or Firm:
INSIGHT INTELLECTUAL PROPERTY LTD. (CN)
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