NANO-CONE STRUCTURE COMPOSITE MATERIAL FOR CAPTURING CANCER CELLS, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Title:

NANO-CONE STRUCTURE COMPOSITE MATERIAL FOR CAPTURING CANCER CELLS, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Document Type and Number:

WIPO Patent Application WO/2018/214430

Kind Code:

A1

Abstract:

A nano-cone structure composite material for capturing cancer cells, a preparation method therefor, and an application thereof, pertaining to the technical field of medical biological materials. The method comprises: first, electrodepositing chlorine-doped polypyrrole on the surface of a conductive substrate by using a chronoamperometry method; then, depositing a nano-cone structured polypyrrole/biotin material on a working electrode by using a chronopotentiometry method, selecting a three-electrode mode, using a conductive metal as a counter electrode and the conductive substrate deposited with polypyrrole as the working electrode, and using a buffer solution containing pyrrole and biotin as an electrolyte; finally, activating the working electrode deposited with the nano-cone structure polypyrrole/biotin material, incubating the working electrode in a streptavidin solution, then grafting the working electrode with an antibody, and incubating the working electrode in a BSA solution, to obtain a nano-cone structure composite material. The method is simple and has low cost. The nano-cone structure in the composite material is stable, and can favorably capture cancer cells and release cancer cells without damage.

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Inventors:

NING CHENGYUN (CN)
WANG ZHENGAO (CN)
YU PENG (CN)
TAN GUOXIN (CN)
HU SHIQIAN (CN)
YAO TIANTIAN (CN)
LUO WEN (CN)

Application Number:

PCT/CN2017/112178

Publication Date:

November 29, 2018

Filing Date:

November 21, 2017

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Assignee:

UNIV SOUTH CHINA TECH (CN)
UNIV GUANGDONG TECHNOLOGY (CN)

International Classes:

C12N5/09; C12N5/00; C25D9/00; C25D9/02

Foreign References:

CN107177553A	2017-09-19
CN103667191A	2014-03-26
CN106222161A	2016-12-14
CN102944598A	2013-02-27
CN106474546A	2017-03-08
JP2014193126A	2014-10-09

Attorney, Agent or Firm:

GUANGZHOU HUAXUE INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)

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