Title:
NANO-NEMIFITIDE LIQUID PHASE PREPARATION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/184316
Kind Code:
A1
Abstract:
Provided is a nano-nemifitide liquid phase preparation method comprising the following steps: 1) preparing intermediate 1H-Trp(Boc)-NH-Dpm with Dpm-NH2 and Fmoc-Trp(Boc)-OH; 2) preparing intermediate 2H-Gly-Trp(Boc)-NH-Dpm; 3) preparing intermediate 3H-Arg(Pbf)-Gly-Trp(Boc)-NH-Dpm; 4) preparing intermediate 4H-4-hydropro(OtBu)-Arg(Pbf)-Gly-Trp(Boc)-NH-Dpm; 5) preparing intermediate 5H-4-Fphe-4-hydropro(OtBu)-Arg(Pbf)-Gly-Trp(Boc)-NH-Dpm; 6) preparing a crude product of nano-nemifitide; and 7) preparing nano-nemifitide by reversed phase chromatography.
Inventors:
CHEN XUE MING (CN)
CHEN XIAO HUAN (CN)
MI PENG CHENG (CN)
TAO AN JIN (CN)
YUAN JIAN CHENG (CN)
CHEN XIAO HUAN (CN)
MI PENG CHENG (CN)
TAO AN JIN (CN)
YUAN JIAN CHENG (CN)
Application Number:
PCT/CN2017/092716
Publication Date:
October 11, 2018
Filing Date:
July 13, 2017
Export Citation:
Assignee:
HYBIO PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K7/06; A61K38/08; A61P25/20
Foreign References:
| CN1151700A | 1997-06-11 |
Other References:
CHEN, YANLI: "Chemical Synthetic Research on Peptide Segments Ligation, Peptide Derivatives and Conjugate of Modifer-peptide Derivative", CMFD MEDICAL AND HEALTH SCIENCES, 15 May 2010 (2010-05-15), ISSN: 1674-0246
Attorney, Agent or Firm:
BEIJING CHENGHUI LAW FIRM (CN)
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