Title:
NANO-SILICA PARTICLES CONTAINING BORON ISOTOPE AND SERVING AS BORON NEUTRON CAPTURE AGENT
Document Type and Number:
WIPO Patent Application WO/2019/181018
Kind Code:
A1
Abstract:
An oligosaccharide and an oligopeptide that exhibit an excellent ability to specifically bind to tumor cells and cancer cells and that can be simply and easily produced are chemically bonded to boron isotope (10B) nano-silica particles in the present invention in order to provide a material enabling drug transport (delivery) with excellent specific accumulation in tumor cells and cancer cells in boron neutron capture therapy (BNCT).
Inventors:
HORI HITOSHI (JP)
TOKUNAGA KEN (JP)
TAKAHASHI MASAO (JP)
TOKUNAGA KEN (JP)
TAKAHASHI MASAO (JP)
Application Number:
PCT/JP2018/035823
Publication Date:
September 26, 2019
Filing Date:
September 19, 2018
Export Citation:
Assignee:
DYNAMIC SCIENCE CORP (JP)
International Classes:
A61K47/69; A61K41/00; A61K51/08; A61K51/12; A61P35/00; C01B33/18
Foreign References:
| KR20160137109A | 2016-11-30 |
Other References:
ABI-GHAIDA FATIMA ET AL.: "Multifunctional Silica Nanoparticles Modified via Silylated-Decaborate Precursors", JOURNAL OF NANOMATERIALS, vol. 2015, 2015, pages 1 - 8, XP055636199, Retrieved from the Internet
ABI-GHAIDA FATIMA ET AL.: "New Triethoxysilylated 10-vertex closo-decaborate clusters. Synthesis and controlled immobilization into mesoporous silica", DALTON TRANSACTIONS, vol. 43, no. 34, 2014, pages 13087 - 13095, XP055636201
LAI CHIAN-HUI: "Trivalent galactosyl-functionalized mesoporous silica nanoparticles as a target-specific dilivery system for boron neutron capture therapy", NANOSCALE, vol. 5, no. 19, 2013, pages 9412 - 9418, XP055636202
ABI-GHAIDA FATIMA ET AL.: "New Triethoxysilylated 10-vertex closo-decaborate clusters. Synthesis and controlled immobilization into mesoporous silica", DALTON TRANSACTIONS, vol. 43, no. 34, 2014, pages 13087 - 13095, XP055636201
LAI CHIAN-HUI: "Trivalent galactosyl-functionalized mesoporous silica nanoparticles as a target-specific dilivery system for boron neutron capture therapy", NANOSCALE, vol. 5, no. 19, 2013, pages 9412 - 9418, XP055636202
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