Title:
NANOBIOSENSOR FOR DETECTING ALLERGIES, MANUFACTURING METHOD THEREFOR, AND DETECTION SYSTEM COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2017/200167
Kind Code:
A1
Abstract:
Provided is a biosensor for detecting allergies, comprising: a substrate; an electrode layer formed on one side of the upper surface of the substrate; a single-walled carbon nanotube layer formed on the other side of the upper surface of the substrate; a linker layer formed on the single-walled carbon nanotube layer; and an antibody fixed and coupled to the linker layer. The nanobiosensor for detecting allergies, according to the present invention, comprises 1-pyrenebutanoic acid succinimidyl ester as a linker on a substrate on which single-walled carbon nanotubes are coated, wherein the linker fixes an antibody capable of capturing allergenic proteins such that when an allergenic protein is captured by the antibody, a change in resistance value occurs, thereby enabling allergenic proteins to be detected with high sensitivity in a short period of time by sensing the changed resistance value.
Inventors:
LEE JIN YOUNG (KR)
OH JUN HYUN (KR)
CHOI HYUN KYUNG (KR)
OH JUN HYUN (KR)
CHOI HYUN KYUNG (KR)
Application Number:
PCT/KR2016/014371
Publication Date:
November 23, 2017
Filing Date:
December 08, 2016
Export Citation:
Assignee:
SANGMYUNG UNIV CHEONAN COUNCIL FOR INDUSTRY ACADEMIC COOPERATION (KR)
International Classes:
G01N33/68; G01N27/04; G01N33/02; G01N33/543; G01N33/544; B82Y15/00; B82Y30/00
Foreign References:
| KR20100023633A | 2010-03-04 | |||
| KR101285375B1 | 2013-07-26 |
Other References:
STEFANSSON S. ET AL: "Targeting Antibodies to Carbon Nanotube Field Effect Transistors by Pyrene HydrazideModification of Heavy Chain Carbohydrates", JOURNAL OF NANOTECHNOLOGY, vol. 2012, 2012, pages 1 - 8, XP0055598272
CHO I: "Development of single-walled carbon nanotube-based biosensor for the detection of Ara h1", KSBB SPRING MEETING AND INTERNATIONAL SYMPOSIUM, 2016
MAEHASHI K. ET AL: "Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors", ANALYTICAL CHEMISTRY, vol. 79, no. 2, 15 January 2007 (2007-01-15), pages 782 - 787, XP055598276
MAEHASHI K. ET AL: "Label-Free Electrical Detection Using Carbon Nanotube-Based Biosensors", SENSORS, vol. 9, no. 7, 8 July 2009 (2009-07-08), pages 5368 - 5378, XP055598278
CHO I: "Development of single-walled carbon nanotube-based biosensor for the detection of Ara h1", KSBB SPRING MEETING AND INTERNATIONAL SYMPOSIUM, 2016
MAEHASHI K. ET AL: "Label-Free Protein Biosensor Based on Aptamer-Modified Carbon Nanotube Field-Effect Transistors", ANALYTICAL CHEMISTRY, vol. 79, no. 2, 15 January 2007 (2007-01-15), pages 782 - 787, XP055598276
MAEHASHI K. ET AL: "Label-Free Electrical Detection Using Carbon Nanotube-Based Biosensors", SENSORS, vol. 9, no. 7, 8 July 2009 (2009-07-08), pages 5368 - 5378, XP055598278
Attorney, Agent or Firm:
KIM, Jung Su (KR)
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